硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的研究进展  

Influence of selenium and n-3 polyunsaturated fatty acids on methylmercury neurotoxicity:a review

作　　者：王菊 吴美琴[2] 颜崇淮[2] WANG Ju WU Mei-qin YAN Chong-huai(School of Public Health ,Shanghai Jiaotong University ,Shanghai 200025 ,China MOE-Shanghai Key Laboratory of Children＇s Environmental Health ,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine ,Shanghai 200092 ,China)

机构地区：[1]上海交通大学公共卫生学院,上海200025 [2]上海交通大学医学院附属新华医院教育部和上海市环境与儿童健康重点实验室,上海200092

出　　处：《中国儿童保健杂志》2017年第10期1034-1037,共4页Chinese Journal of Child Health Care

基　　金：国家自然科学基金(81472993);科技部973课题(2012CB525001)

摘　　要：水产品是人类甲基汞暴露的来源之一,同时包含多种对神经系统发育有重要作用的营养物质,如硒、n-3多不饱和脂肪酸。目前,多项研究提示硒与n-3多不饱和脂肪酸对甲基汞神经毒性可能具有潜在的保护作用。本文回顾了硒与n-3多不饱和脂肪酸对甲基汞神经毒性影响的流行病学与实验研究,重点讨论了其与甲基汞可能的相互作用及作用机制,在此基础上对未来的研究方向进行展望。Aquatic products are one of sources of methylmercury exposure for human beings,and also contain a number of nutrients which have significant effects on nervous system development,such as selenium and n-3polyunsaturated fatty acids.Recent researches have indicated that selenium and n-3polyunsaturated fatty acids might provide potential protection against methylmercury neurotoxicity.This paper reviewes both epidemiological and experimental studies about the influence of selenium and n-3polyunsaturated fatty acids on methylmercury neurotoxicity.The possible interaction between two materials and methylmercury,and the underlying mechanisms are discussed as emphases,so as to provide evidence for futher research.

关 键 词：甲基汞 硒 N-3多不饱和脂肪酸 神经毒性 

分 类 号：R179[医药卫生—妇幼卫生保健]