Construction of Redox Responsive Vesicles Based on a Supra-Amphiphile for Enzyme Confinement  

作　　者：Tiezheng Pan Huixin Zou Hongcheng Sun Yao Liu Shengda Liu Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu 

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin 130012, China

出　　处：《Chinese Journal of Chemistry》2017年第6期871-875,共5页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （（Nos. 21420102007, 21234004, 21574056, 91527302）, the Chang Jiang Scholars Program of China, and Project 2016014 Sup- ported by Graduate Innovation Fund of Jilin University.

摘　　要：Redox responsive vesicles were constructed based on guest interaction between fl-cyclodextrin and a ferrocene self-assembly of a supra-amphiphile built by the host- derivative. The structure and destruction-reconstruction reversibility of the ＂smart＂ vesicles were clearly characterized by electron microscopy and dynamic light scattering. Notably, these vesicles were proved to be capable of controlled release function and bringing protease resistance to the enzyme, showing great biocompatibility and promising applications.Redox responsive vesicles were constructed based on guest interaction between fl-cyclodextrin and a ferrocene self-assembly of a supra-amphiphile built by the host- derivative. The structure and destruction-reconstruction reversibility of the ＂smart＂ vesicles were clearly characterized by electron microscopy and dynamic light scattering. Notably, these vesicles were proved to be capable of controlled release function and bringing protease resistance to the enzyme, showing great biocompatibility and promising applications.

关 键 词：redox responsive host-guest systems vesicles supra-amphiphile glutathione S-transferase 

分 类 号：O621.254[理学—有机化学] S852.659.7[理学—化学]