高迁移率族蛋白B1和C-反应蛋白水平与冠心病患者冠脉斑块形态及冠心病病情的关系  

Relationship of high mobility group protein B1 and CRP levels with coronary plaque morphology and coronary heart disease in patients with coronary heart disease

作　　者：贠利新[1] 王琦[2] 王琳[3] 

机构地区：[1]广西钦州市第一人民医院心血管内科,广西钦州535099 [2]广西钦州市第一人民医院肿瘤内科,广西钦州535099 [3]广西南宁市第一人民医院医学检验科,广西南宁530022

出　　处：《中国卫生检验杂志》2017年第17期2518-2520,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨冠心病患者血清中HMGB1和CRP水平与冠心病患者冠脉斑块形态及冠心病病情的关系。方法选择2015年8月-2016年8月本院收治的92例冠心病患者作为研究对象,采用酶联免疫吸附法检测患者血清中HMGB1和CRP水平,行冠状动脉造影评价患者冠心病病情,行冠脉CT判断冠状动脉斑块性质,探讨患者血清中HIMGB1和CRP水平与患者冠脉性质和冠心病病情的关系。结果根据HMGB1和CRP中位数分为高水平组和低水平组,HMGB1高水平组、CRP高水平组患者冠脉软斑块均多于对应低水平组;HMGB1高水平组患者冠脉多支病变数多于低水平组,CRP高水平组患者冠脉重度闭塞、完全闭塞数多于对应低水平组患者,差异均有统计学意义(P<0.05)。结论高水平的HMGB1和CRP患者冠脉病变程度越严重,软斑块发病率越高。Objective To investigate the relationship of serum high mobility group protein B1（ HMGB1） and CRP levels with coronary plaque morphology and coronary heart disease in patients with coronary heart disease. Methods 92 patients with coronary heart disease from August 2015 to August 2016 in the hospital were selected,the serum levels of HMGB1 and CRP were detected by enzyme-linked immunosorbent assay to evaluate the coronary angiography in patients with coronary heart disease and coronary artery disease,CT was used to determine the nature of coronary artery plaque,so as to discuss the relationship of serum HIMGB1 and CRP levels in patients with coronary artery nature and the severity of coronary heart disease. Results According to the results of HMGB1 and CRP,patients were divided into high level group and low level group; the high level of HMGB1 group and CRP group had more coronary artery with soft plaques than the corresponding lower level group; the high level of HMGB1 in patients had more multivessel coronary disease variabilities than low level group,the high level of CRP patients had more severe coronary artery occlusion and total occlusion number than the corresponding low level group,with the differences statistically significant（ P〈0. 05）. Conclusion The higher the level of coronary lesions in patients with HMGB1 and CRP is,the higher the incidence of soft plaque is.

关 键 词：冠心病 冠脉病变 斑块类型 高迁移率族蛋白B1 

分 类 号：R541.4[医药卫生—心血管疾病]