脓毒症内皮系统损伤与器官功能障碍的关联  

Association between endothelial injury and organ dysfunction in sepsis

作　　者：张天楠 曾其毅[1] 

机构地区：[1]南方医科大学珠江医院儿科中心,广州510282

出　　处：《中华实用儿科临床杂志》2017年第18期1438-1440,共3页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金（81272070）

摘　　要：脓毒症是宿主因病原体感染而发生的全身系统性免疫反应，在《第三版国际脓毒症定义共识及相关临床标准》中强调了器官功能障碍的发生。脓毒症的病理生理过程复杂，内皮系统损伤是脓毒症的特征之一，表现为微循环调控障碍、屏障功能丧失、免疫细胞侵袭组织等，导致器官缺血、水肿、炎性损伤进而出现器官功能障碍。近年来对内皮糖萼的研究认为，糖萼在脓毒症内皮损伤中也起到重要作用。随着脓毒症内皮系统损伤与器官功能障碍发生机制的研究深入，临床评估技术与临床试验也有新的进展。The definition of sepsis has been updated as life - threatening organ dysfunction caused by a dysre- gulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock （ SEPSIS - 3 ）. Sepsis affects functions of endothelial cell （EC） which include vasoregulation, barrier function, infla- mmation, hemostasis, and is thought to be the key factor in the progression from sepsis to organ failure. Recent studies also demonstrated the mechanism of endothelial dysfunction in sepsis is mediated by glycocalyx shedding. This review covers the current insight in sepsis - associated endothelial dysfunction in different organ systems, as well as the clinical assessment and clinical trial aiming at the system of endothelium.

关 键 词：脓毒症 血管内皮 糖萼 器官功能障碍 

分 类 号：R459.7[医药卫生—急诊医学]