信号转导与转录激活因子4基因多态性与子痫前期的相关性研究  

Association of Polymorphisms of Signal Transducer and Activator of Transcription 4 with the Susceptibility to Preeclampsia

作　　者：李银广[1] 李珠玉[1] 李婕[1] 侯文汇 李小青[1] 林敏欢 游泽山[1] LI Yin-guang LI Zhu-yu LI Jie HOU Wen-hui LI Xiao-qing LIN Min-huan YOU Ze-shan(Department of Obstetrics and Gynecology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院妇产科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2017年第5期705-709,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(S2011010003522)

摘　　要：【目的】探讨信号转导与转录激活因子4(STAT4)基因rs10181656及rs16833431位点多态性与子痫前期相关性的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者(病例组)和179名健康孕妇(对照组)的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】(1)rs10181656位点在病例组中C/C、C/G及G/G基因型频率分别是35.96%、47.81%及16.23%,而对照组中的三种基因型的频率分别是46.37%、44.69%及8.94%,C/C、C/G及G/G基因型频率在病例组和对照组中分布具有统计学差异(P=0.031),C、G等位基因频率在病例组和对照组中分布具有统计学差异(P=0.009);(2)rs16833431位点:三种基因型和C、T等位基因频率在病例组和对照组的分布无统计学意义(P=0.508,0.461)。【结论】STAT4基因rs10181656位点多态性与子痫前期相关,而rs16833431位点多态性与子痫前期发病无关。【Objective】To investigate associations between the functional polymorphisms of signal transducer and activator of transcription 4（STAT4）gene and preeclampsia.【Methods】PCR-restriction fragment length polymorphism was used to genotype rs10181656 and rs16833431 local polymorphism in 228 preeclampsia cases and 179 normal controls.【Results】（1）The frequencies of rs10181656C/G were 35.96%,46.37% in genotype C/C,47.81%,44.69% in genotype C/G and 16.23%,8.94% in genotype G/G between preeclampsia patients and normal controls. They reached statistical difference（P = 0.031）. There was different distribution in two alleles（C and G）between preeclampsia patients and normal controls（P = 0.009）.（2）There was no different distribution in 3genotypes（C/C,C/T,T/T）and 2 alleles（C and T）of rs16833431 C/T between preeclampsia patients and normal controls（P =0.508,0.461）.【Conclusions】Functional polymorphisms of the rs10181656 locus could associate with the preeclampsia. The polymorphisms of the rs16833431 locus could not associate with the preeclampsia.

关 键 词：子痫前期 信号转导与转录激活因子4 基因多态性 

分 类 号：R714.2[医药卫生—妇产科学]