假马齿苋的化学成分和药理活性研究进展  

Research progress on chemical constituents from Bacopa monnieri and their pharmacological activities

作　　者：祖先鹏 林璋[2] 谢海胜 顾彧 张卫东[1,2,3] 

机构地区：[1]第二军医大学药学院,上海200433 [2]上海交通大学药学院,上海200240 [3]上海中医药大学交叉科学研究院,上海201203

出　　处：《中草药》2017年第18期3847-3863,共17页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81230090;81520108030;2011ZX09307-002-03);上海市活性天然产物制备工程技术研究中心项目(16DZ2280200)

摘　　要：通过检索假马齿苋Bacopa monnieri的化学成分及其药理活性的相关文献,发现其化学成分类型主要包括三萜及其苷类、黄酮类、苯乙醇苷类、甾醇类等。现代药理学研究证明,假马齿苋对中枢神经、心血管、消化、呼吸、内分泌等系统均有一定的影响,此外还具有抗炎镇痛、抗氧化、降血糖、抗肿瘤、抗微生物以及肝肾保护等药理活性。现对该植物的化学成分以及药理活性进行综述,为其后期深入研究和开发提供科学依据。The revelant literatures about chemical constituents from the plant Bacopa monnieri and their pharmacological activities were consulted and summarized. The plant contains major chemical compounds including triterpenoids and their glycosides, flavonoids, phenylethanoid glycosides and sterols. It has the impact on central nervous system, cardiovascular system, digestive system, respiratory system and endocrine system, in addition to anti-inflammatory, analgesic, anti-oxidation, hypoglycemic, antitumor, anti-microbial and liver and kidney protection and other pharmacological activities. This paper reviewed the chemical compositions and pharmacological activities, and provided a scientific basis for further research and development of the plant.

关 键 词：假马齿苋 三萜皂苷 黄酮类 中枢神经系统 心血管系统 抗氧化 抗炎镇痛 

分 类 号：R282.71[医药卫生—中药学]