天然产物中的AMPK激活剂研究进展  

Research progress on AMPK activators from natural products

作　　者：赵力挥 王璐 刘文丽[3] 王国成[1] 

机构地区：[1]天士力控股集团有限公司天士力研究院,天津300410 [2]内蒙古医科大学药学院,内蒙古呼和浩特010110 [3]江苏天士力帝益药业有限公司,江苏淮安223003

出　　处：《中草药》2017年第18期3885-3896,共12页Chinese Traditional and Herbal Drugs

摘　　要：单磷酸腺苷活化蛋白激酶(AMPK)被称为真核细胞的"能量感受调节器",是治疗高脂血症和糖尿病等代谢性疾病的药物靶点之一。天然产物种类繁多、结构多样,是药物发现的重要来源。按照天然产物的结构分类,综述了来源于天然产物的AMPK激活剂研究进展,为AMPK激活剂类药物的开发提供有益参考。Adenosine monophosphate activated protein kinase（AMPK）, known as the ＂energy sensor＂ of eukaryotic cells, is one of the targets for the treatment of metabolic diseases such as hyperlipidemia and diabetes. Natural products, with tremendous structural diversity, were an important source for drug discovery. Research progress on AMPK activators derived from natural products was reviewed according to the classification of structure, which provided a useful reference for the drug development of AMPK activators.

关 键 词：单磷酸腺苷活化蛋白激酶 激活剂 天然产物 高脂血症 糖尿病 

分 类 号：R285[医药卫生—中药学]