心脏彩色多普勒超声评价压力负荷超载诱导的舒张性心力衰竭及益气温阳中药的干预作用  

PWD is a Useful Tool for Evaluation of Cardiac Diastolic Function in a Rat Model of Pressure Overload and the Therapeutic Effect of Tonifying Qi and Warming Yang Medicine

作　　者：鲁成[1,2] 宋磊[1] 蒋梅先[1] 沈睿[3] 刘永明[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海中医药大学附属第七人民医院,上海200137 [3]上海中医药大学附属上海市中医医院,上海200071

出　　处：《辽宁中医杂志》2017年第9期1978-1982,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81102671);上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY002)

摘　　要：目的:通过心脏彩色多普勒超声评价压力负荷超载诱导的舒张性心力衰竭及益气温阳中药的干预作用。方法:清洁级雄性Wistar大鼠40只,随机选取10只为假手术组,余30只腹主动脉缩窄术后,随机分为模型组、中药组、缬沙坦组,每组10只。造模后8周开始药物干预,共干预16周。观察药物干预对心脏彩色多普勒超声的影响。结果:1.心肌形态测量学:造模24周后,模型组大鼠CMI、LVMI明显增加(P<0.05),中药组的CMI、LVMI和模型组相比差异无统计学意义(P>0.05),缬沙坦组CMI、LVMI和模型组相比差异有统计学意义(P<0.05),中药组CMI、LVMI与西药组相比差异无统计学意义(P>0.05)。2.M型超声心动图:(1)造模24周后,模型组大鼠IVSd显著增高(P<0.05),中药组IVSd与模型组相比有减小趋势,差异无统计学意义(P=0.069),缬沙坦组IVSd与模型组相比明显减小(P<0.05),中药组IVSd与缬沙坦组相比差异无统计学意义(P>0.05)。(2)造模24周后,模型组大鼠LV Mass增大(P<0.05),中药组LV Mass与模型组相比有统计学差异(P<0.05),缬沙坦组LV Mass与模型组相比差异有统计学意义(P<0.05),中药组LV Mass与缬沙坦组相比差异无统计学意义(P=NS)。(3)造模24周后,模型组大鼠LVIDd明显增大(P<0.05),中药组LVIDd较模型组减小(P<0.05),缬沙坦组LVIDd和模型组比较差异没有统计学意义(P>0.05),中药组LVIDd与缬沙坦组相比差异无统计学意义(P>0.05)。(4)造模24周后,模型组大鼠EF、FS降低,但差异无统计学意义(P>0.05),中药组、缬沙坦组和模型组相比差异无统计学意义(P>0.05,P>0.05),中药组和缬沙坦组相比差异无统计学意义(P>0.05)。3.心脏彩色血流多普勒超声:(1)造模24周后,模型组E峰显著减小(P<0.05);中药组E峰较模型组增大(P<0.05);缬沙坦组和模型组比较差异无统计学意义(P>0.05),中药组与缬沙坦组相比差异无统计学意义(P>0.05)。(2)模型组E/A比值显著降低(P<0.05),中药组E/A比�Objective： To evaluate cardiac diastolic function in a rat model of diastolic heart failure induced by pressure overload and the therapeutic effect of tonifying Qi and warming Yang medicine by means of echocardiography. Methods： Forty male Wistar rats,clean grade,10 received a sham operation,while 30 had an abdominal aortic constriction surgery. The rats with abdominal aortic constriction surgery were randomly divided into three groups： a control group,a TCM group and a valsartan group,each group 10 rats. Cardiac functions were studied in each group of rats at the end of 16 weeks after treatment. Results： 1. ventricular morphology： After 24 weeks,the CMI and LVMI were increased in the control group（ P〈0. 05）. While there were no significant difference between the control group and the TCM group（ P〈0. 05）. Compared with the control group,the CMI and LVMI were decreased in the Valsartan group（ P〈0. 05）. There were no significant difference between the TCM group and the Valsartan group（ P〈0. 05）. 2. M-mode echocardiography：（ 1） After 24 weeks,the IVSd was increased in the control group（ P〈0. 05）.While there were no significant difference between the control group and the TCM group（ P = 0. 069）. Compared with the control group,the IVSd was decreased in valsartan group（ P〈0. 05）. There were no significant difference between the TCM group and the Valsartan group（ P〈0. 05）.（ 2） After 24 weeks,LV Mass was increased in the control group（ P〈0. 05）. Compared with the control group,the LV Mass was decreased in TCM group（ P〈0. 05）. Compared with the control group,the LV Mass was decreased in valsartan group（ P〈0. 05）. There were no significant difference between the TCM group and the Valsartan group（ P〈0. 05）.（ 3） After 24 weeks,the LVIDd was increased in the control group（ P〈0. 05）. Compared with the control group,the LVIDd was decreased in TCM group（ P〈0. 05）. There were no significant difference between the control gro

关 键 词：益气温阳中药 舒张性心力衰竭 腹主动脉缩窄 心脏彩色多普勒超声 

分 类 号：R541.6[医药卫生—心血管疾病]