MicroRNA-29在肾纤维化进程中的研究进展  

Advances in the roles of microRNA-29 in renal fibrosis

作　　者：刘祎[1] 孙雪娇[1] 李城[1] 王曦廷 李彧[1] LIU Yi SUN Xue-jiao LI Cheng WANG Xi-ting LI Yu(College of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, china)

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《解剖学报》2017年第5期622-627,共6页Acta Anatomica Sinica

基　　金：国家自然科学基金(81573716)

摘　　要：肾纤维化是慢性肾脏疾病(CKD)发展到终末期肾衰竭的共同病理,主要表现为细胞外基质(ECM)的过度沉积。MicroRNAs(miRNAs)是一类微小非编码RNAs,通过抑制目的基因mRNAs转录后的表达而调控肾脏的生理功能及稳态。miR-29s通过调节ECM的合成与沉积以及上皮-间质转化(EMT)发挥抗纤维化作用,另外,miR-29s与多种炎症和促纤维化通路相互作用,其作为治疗肾纤维化的试剂或者靶点研究有着重要意义和广泛前景。本文中我们综述了最近有关miR-29s抗肾纤维化作用的研究成果。One of the histopathological features of Chronic kidney disease （CKD） is renal fibrosis which is accompanied by the deposition of extracellular matrix （ ECM）. MicroRNAs are short non-coding RNAs that regulate most of important processes about renal physiological functions and homeostatsis, miR-29s are involved in the pathogenesis of fibrosis by regulating ECM production and deposition, and epithelial-mesenchymal transition （EMT）. In this review, we describe interactions of miR-29s with multiple pro-fibrotic and inflammatory pathways and miR-vs as a promising therapeutic reagent or target for the treatment of renal fibrosis. We also review the mechanism of microRNA-29s associated with renal fibrosis.

关 键 词：细胞外基质 上皮细胞-间充质转化 miRNA-29 肾纤维化 

分 类 号：R692[医药卫生—泌尿科学]