细菌三型分泌系统效应蛋白转运的研究进展  

Advances in studies of translocation of effector by bacterial type 3 secretion system

作　　者：孙思 牛建军[2,3,4] 王岱 Si Sun Jianjun Niu Dai Wang(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen 361102, Fujian Province, China Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China Public Health School of Xiamen University, Xiamen 361102, Fujian Province, China Public Health School of Fujian Medical University, Fuzhou 350004, Fujian Province, China)

机构地区：[1]厦门大学分子疫苗学和分子诊断学国家重点实验室,福建厦门361102 [2]厦门大学附属中山医院,福建厦门361004 [3]厦门大学公共卫生学院,福建厦门361102 [4]福建医科大学公共卫生学院,福建福州350004

出　　处：《微生物学报》2017年第10期1452-1460,共9页Acta Microbiologica Sinica

基　　金：国家自然科学基金(31370166;81473251;81301474);福建省自然科学基金(2014J01139;2015J01345);厦门大学校长基金(20720160060)~~

摘　　要：三型分泌系统(Type 3 secretion system,T3SS)作为存在于革兰氏阴性菌中的分泌系统之一,对革兰氏阴性菌的致病有重要作用。T3SS的致病作用体现在T3SS能直接将效应蛋白转运至宿主细胞,进而通过效应蛋白调控细胞的一系列通路,促进细菌定殖于细胞。而效应蛋白的转运受到两方面因素的调控,一方面是效应蛋白本身的信号序列,另一方面是T3SS相关蛋白的辅助。本文围绕近年来T3SS的构成、效应蛋白转运机制方面的最新进展进行概要综述。Type 3 secretion system, as one of the secretion systems for Gram-negative bacterial, plays an important role in the pathopoiesia of Gram-negative bacteria. Bacteria can use T3SS as a canal that directly translocates effectors to host cell. Effectors in host cell manipulate a subset of signaling pathways of host cell to promote bacterial colonization in cells. The translocation of effectors is regulated by two factors, one is the signal sequences of effector, and the other is the regulation of T3SS-associated proteins. In this article, we review recent advances in studies on the constitute of T3SS and the mechanism ofeffectors translocation.

关 键 词：三型分泌系统 效应蛋白 转运 分泌信号 

分 类 号：Q936[生物学—微生物学]