4种石斛的多糖对高血压大鼠降血压的影响  

Antihypertensive Effects of Polysaccharides from Four Dendrobium Species on Hypertensive Rats

作　　者：王再花 叶庆生[2] 李杰 章金辉 徐晔春 

机构地区：[1]广东省农业科学院环境园艺研究所/广东省园林花卉种质创新综合利用重点实验室,广东广州510640 [2]华南师范大学生命科学学院,广东广州510631

出　　处：《热带作物学报》2017年第9期1764-1767,共4页Chinese Journal of Tropical Crops

基　　金：广东省农业标准化研究项目"铁皮石斛有机种植标准研制";国家青年科学基金(No.31400597);广东省科技计划项目(No.2013B020302009);广东省园林花卉种质创新综合利用重点实验室开放课题项目(No.HY201501)

摘　　要：以铁皮石斛、金钗石斛、大苞鞘石斛和春石斛品种(Dendrobium Second Love‘Tokimeki’)为试材,研究4种石斛茎段的不同纯度多糖(粗多糖CDPs、精多糖DPPs和纯化多糖水洗组分DPPs-I)对自发性高血压大鼠(SHR)体内降血压效果的影响。结果表明,4种石斛的不同纯度多糖均对SHR具有降血压的效果,且处理时间越长效果越显著,处理240 min后均显著优于阳性对照硝苯地平。金钗石斛多糖水洗组分(DNPP-I)在240 min内降血压效果好于其对应的粗多糖和精多糖,而铁皮石斛、大苞鞘石斛和春石斛品种D.Second Love‘Tokimeki’的各多糖间降血压效果差异不显著。4种石斛DPPs-I间降血压作用无显著差异。本研究显示石斛多糖具有一定的降血压活性,其中纯化多糖水洗组分DPPs-I具有较好的降血压效果,药用开发前景良好。To investigate the antihypertensive activities of the polysaccharides from the stems of 4 Dendrobium species（Dendrobium officinale, Dendrobium nobile, Dendrobium wardianum and Dendrobium Second Love ‘Tokimeki＇）,the antihypertensive effects of crude polysaccharides, purified polysaccharides and polysaccharide fractions were determined by hypertensive rats in this study. The results showed that all polysaccharides from the 4 Dendrobiumn species had antihypertensive effects on spontaneously hypertensive rats（ SHR）, and they significantly decreased blood pressure in rats with the increasing of polysaccharide purity or time extention, and significantly higher than nifedipine（positive control） after treatment for 240 min. The antihypertensive effects of the polysaccharide fractions from D. nobile were better than the crude polysaccharides and purified polysaccharides, while the three kinds of polysaccharides were insignificant in D. officinale, D. wardianum or D. Second Love ‘ Tokimeki＇. Among the 4polysaccharide fractions from the 4 species, there was no significant difference to reduce blood press. It was suggested that all polysaccharides from the 4 Dendrobium species showed certain antihypertensive activities, and the polysaccharide fractions had better antihypertensive effects, which had a good medicinal prospect.

关 键 词：石斛 多糖 高血压大鼠 降血压活性 

分 类 号：R284.1[医药卫生—中药学]