山东沿海居民血清尿酸水平与游离脂肪酸的相关性研究  

Correlation study on the serum uric acid and free fatty acid levels of Shandong coastal inhabitants

作　　者：邱铭月 王栾 侯旭[1] 车奎 陈颖[1] 王忠超[1] 吕文山[1] 赵世华[1] 王颜刚[1] 

机构地区：[1]青岛大学附属医院内分泌与代谢病科,266003

出　　处：《中华内分泌代谢杂志》2017年第9期765-768,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：探讨山东沿海地区居民的血清尿酸水平与游离脂肪酸（FFA）的相关性。采用随机、分层、整群抽样的方法，调查青岛、烟台、威海、日照长住居民3 860人血清尿酸水平与FFA的相关性。根据FFA四分位数将受试者分为4组：Q1组908名、Q2组1 016名、Q3组958名、Q4组978名，高尿酸血症患病率及血尿酸水平随着FFA四分位数的升高而升高，与Q1、Q2、Q3组相比较，Q4组高尿酸血症患病率、血尿酸的升高具有统计学意义（P〈0.05），且Q4组高尿酸血症患病率是Q1组的2.0倍。根据血尿酸水平将受试者分为尿酸正常组3 331名和高尿酸血症组529例，高尿酸血症组收缩压、舒张压、腰围、臀围、三酰甘油、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、血糖、尿酸、FFA、体重指数等指标明显高于尿酸正常组（均P〈0.01），而高密度脂蛋白胆固醇（HDL-C）、胱抑素、估算的肾小球滤过率（eGFR）明显低于尿酸正常组（均P〈0.01）。受试者血尿酸水平与收缩压、舒张压、腰围、臀围、三酰甘油、总胆固醇、LDL-C、FFA、血糖、体重指数呈正相关（均P〈0.01），与eGFR呈负相关（P〈0.01）。多元逐步回归分析显示，收缩压、FFA、三酰甘油、总胆固醇、LDL-C、体重指数、eGFR是影响血尿酸的独立相关因素。多因素二分类logistic回归分析显示收缩压、腰围、总胆固醇、血糖、FFA是预测调查者高尿酸血症发病的独立危险因素，eGFR是其保护因素。血清尿酸水平与FFA关系密切，FFA参与高尿酸血症的发生、发展。To evaluate the correlation of the serum uric acid and free fatty acid （FFA） levels in Shandong coastal residents. To investigate the correlation between serum uric acid and FFA based on 3 860 individuals who have been long staying in Qingdao, Yantai, Weihai, Rizhao with a randomized, stratified cluster sampling method. According to FFA quartile, subjects were divided into four groups ： group Q1 of 908, group Q2 1 016, group Q3 958, and group Q4 978 cases. The prevalence of hyperuricemia and serum uric acid levels increased with the increasing FFA quartile. Compared with Q1, Q2, and Q3 groups, the prevalence ofhyperuricemia in Q4 group and the increase of serum uric acid were statistically significant （ P〈O. 05 ）. And in the group Q4, hyperuricemia prevalence is twice as the group A. According to the serum uric acid level, subjects were divided into the normal uric acid group （ n = 3 331 ） and the hyperuricemia group （ n = 529 ）. In the hyperuricemia group, their systolic blood pressure, diastolic blood pressure, waist circumference, hip circumference, triglycerides, total cholesterol, low density lipoprotein-cholesterol （ LDL-C）, glucose, uric acid, FFA, body mass index etc. were significantly higher than those of the normal uric acid group （all P〈0.01 ）, while the high density lipoprotein-cholesterol （HDL-C）, cystatin, glomerular filtration rate （eGFR） are significantly lower than those of the normal uric acid group （ all P〈0. 01 ）. Serum uric acid levels are positively correlated with systolic and diastolic blood pressures, waist and hip circumferences, triglycerides, total cholesterol, LDL-C, FFA, blood glucose, body mass index （ all P〈0.01 ） ; and negatively correlated with eGFR （ P〈 0.01 ）. Multiple regression analysis showed that systolic blood pressure, FFA, total cholesterol, triglycerides, LDL-C, blood glucose, body mass index, eGFR were factors influencing serum uric acid independently. Multivariate binary logistic regression analysis showed that

关 键 词：尿酸 游离脂肪酸 危险因素 

分 类 号：R589.7[医药卫生—内分泌]