天然药物化学史话:阿维菌素和伊维菌素  

Historical story on natural medicinal chemistry: Avermectin and ivermectin

作　　者：付炎 王于方 李力更 霍长虹 吴一兵 张嫚丽 史清文 

机构地区：[1]河北医科大学药学院天然药物化学教研室,河北石家庄050017

出　　处：《中草药》2017年第17期3453-3462,共10页Chinese Traditional and Herbal Drugs

基　　金：河北医科大学教育科学研究课题(2014yb-21;2016yb-9);2016年河北医科大学校内科研发展基金(kyfz111);国家青年自然科学基金(81602978)

摘　　要：微生物是天然产物的一大来源,许多来自微生物的天然产物已被开发成药物用于治疗人类疾病,或作为兽药、农药等发挥了重要的作用。来源于放线菌Streptomyces avermectinius的阿维菌素是第1个大环内酯类抗寄生虫药物,其半合成衍生物伊维菌素可用于治疗人类河盲症与象皮病。2位科学家因研发阿维菌素和伊维菌素做出的巨大贡献而获得诺贝尔奖。回顾阿维菌素到伊维菌素的研发历程,以期给予从事相关研究的科学工作者以激励与启迪。Microorganisms have provided abundant sources of natural products, which have been developed as commercial products for human medicine, animal health, and plant crop protection. Avermectin discovered from Streptomyces avermectinius was the first macrocyclic lactones against parasitic worms. The semi-synthetic derivative of avermectin, ivermectin, was used to treat onchocerciasis and lymphatic filariasis in human. Two scientists were awarded the Nobel Prize for the great contribution to the discovery and research of these drugs. This paper reviewed the study and development of avermectins and ivermectin. This is one of the series papers about historical story on natural medicinal chemistry.

关 键 词：天然药物化学 微生物 阿维菌素 伊维菌素 新药发现 

分 类 号：R284[医药卫生—中药学]