维生素C棕榈酸酯在肿瘤治疗中的研究进展  

Research advances of palmitoyl ascorbate in the tumor treatment

作　　者：杨越 鲁晓雨 李宁[2] 赵娣 卢杨 陈西敬 

机构地区：[1]中国药科大学基础医学与临床药学学院临床药物代谢动力学研究室,江苏南京211198 [2]中国药科大学药物代谢与动力学研究中心,江苏南京211198

出　　处：《药学研究》2017年第9期527-530,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81473272)

摘　　要：近年来,维生素C的抗肿瘤作用已引起了人们的广泛关注,但维生素C需较高剂量才可达到抗肿瘤作用,且化学性质不稳定,使其临床应用受到了限制。为了解决上述问题,研究者一直致力于维生素C衍生物的合成。维生素C棕榈酸酯作为维生素C的脂溶性衍生物,在理化性质、抗肿瘤活性等方面具有较多的优势。本文从维生素C棕榈酸酯的理化特征、抗肿瘤活性、机制和应用等方面对其在肿瘤治疗中的研究情况进行综述,为其在临床肿瘤防治中的研究提供依据。In recent years,the antitumor effect of vitamin C has attracted widespread attention.However,its clinical anticancer application is compromised by the need for extremely high dose and chemical instability. In order to overcome the aforementioned limitations,researchers are committed to synthesize its derivative. Palmitoyl ascorbate as a lipophilic derivative of vitamin C shows the advantages in physicochemical properties and anticancer activity. This paper reviewed its physicochemical characteristics,anticancer activity,anticancer mechanisms and applications in the cancer treatment.The review aimed to provide useful information for the clinical application of palmitoyl ascorbate.

关 键 词：维生素C棕榈酸酯 抗肿瘤 研究进展 

分 类 号：R979.1[医药卫生—药品]