胎儿宫内窘迫的脐血流超声参数与胎儿缺血缺氧性损伤程度的相关性  

The correlation between the umbilical artery flow ultrasound parameters of intrauterine fetal distress and fetal ischemic hypoxic damage

作　　者：顾海英[1] 刘鹏云 李映雪 

机构地区：[1]中国石油集团东方地球物理勘探有限责任公司中心医院功能科,河北徐水072555

出　　处：《海南医学院学报》2017年第16期2233-2235,2239,共4页Journal of Hainan Medical University

基　　金：保定市科技支撑计划项目(17ZF078)~~

摘　　要：目的:胎儿宫内窘迫的脐血流超声参数与胎儿缺血缺氧性损伤程度的相关性。方法:选择在我院分娩的158例产妇,根据新生儿Apgar评分分为宫内窘迫组(Apgar<7分)和正常妊娠组(Apgar≥7分),测定孕24~30周、31~36周、37~41周时的脐血流超声参数,测定脐动脉的血气参数及氧化应激分子含量。结果:孕24~30周、31~36周、37~41周期间,宫内窘迫组孕妇的脐动脉RI、PI、S/D均显著高于正常妊娠组;宫内窘迫组的脐动脉pH值、PaO2显著低于正常妊娠组且与RI、PI、S/D呈负相关,PaCO2、乳酸含量显著高于正常妊娠组且与RI、PI、S/D呈正相关;宫内窘迫组产妇脐动脉中SOD、GSH-px、CAT的含量显著低于正常妊娠组且与RI、PI、S/D呈负相关,MDA、8-OHdG的含量显著高于且正常妊娠组与RI、PI、S/D呈正相关。结论:胎儿宫内窘迫的脐血流超声特征表现为阻力增加、血流减少且与胎儿缺氧程度、氧化应激程度相关。Objective：To study the correlation between the umbilical artery flow ultrasound parameters of intrauterine fetal distress and fetal ischemic hypoxic damage.Methods：A total of 158 puerperae who gave birth in our hospital between July2016 and June 2017 were selected and divided into the intrauterine distress group（Apgar7points）and normal pregnancy group（Apgar≥7points）according to the neonatal Apgar score.The umbilical artery flow ultrasound parameters at 24-30 weeks,31-36 weeks and 37-41 weeks of gestation were determined,and the umbilical arterial blood gas parameters and oxidative stress molecule levels were determined.Results：At 24-30 weeks,31-36 weeks and 37-41 weeks of gestation,umbilical arterial RI,PI and S/D of intrauterine distress group were significantly higher than those of normal pregnancy group;umbilical arterial pH and PaO2 of intrauterine distress group were significantly lower than those of normal pregnancy group and negatively correlated with RI,PI and S/D while PaCO2 and lactic acid levels were significantly higher than those of normal pregnancy group and positively correlated with RI,PI and S/D;SOD,GSH-px and CAT levels in umbilical artery of intrauterine distress group were significantly lower than those of normal pregnancy group and negatively correlated with RI,PI and S/D while MDA and 8-OHdG levels were significantly higher than those of normal pregnancy group and positively correlated with RI,PI and S/D.Conclusions：Umbilical artery flow ultrasound of intrauterine fetal distress is characterized by the increased resistance and decreased blood flow and is correlated with the degree of fetal hypoxia and oxidative stress.

关 键 词：胎儿宫内窘迫 超声 脐动脉 血气分析 氧化应激 

分 类 号：R714.43[医药卫生—妇产科学]