环境响应性嵌段共聚物的合成、自组装及应用研究进展  

Progress in Syntheses,Self-Assembly and Applications of Environmental Responsive Block Copolymers

作　　者：魏渊[1] 郑成[1,2] 毛桃嫣 林璟[1] 凌慧[1] Wei Yuan Zheng Cheng Mao Taoyan Lin Jing Ling Hui(Institute of Fine Chemical Engineering of Guangzhou University, Guangzhou 510006 Guangzhou Vocational College of Science and Technology, Guangzhou 510550)

机构地区：[1]广州大学精细化工研究所,广州510006 [2]广州科技职业技术学院,广州510550

出　　处：《化学通报》2017年第10期925-934,共10页Chemistry

基　　金：国家自然科学基金项目(2167606)资助

摘　　要：近年来具有环境响应性的嵌段共聚物的研发受到了人们的广泛关注。该类型共聚物可以对外界环境刺激产生相应的结构、物理及化学性能的变化。根据外界环境刺激响应机理及类型的不同,可将其分为单一因素、双重因素以及三重因素刺激响应性嵌段共聚物三大类。针对每一类体系,本文重点综述了嵌段共聚物的设计合成、自组装以及应用等研究现状,并概括总结了各种有序聚集体(如胶束、囊泡等)随外界环境刺激(如pH、温度、光、CO_2、氧化还原剂等)所作出的响应性变化。最后,对智能型嵌段共聚物在药物控释、纳米容器制备、生物功能材料等方面潜在的应用价值和今后可能的发展方向进行了展望。In recent years,the research of environmentally responsive block copolymers has attracted wide attention from researchers. The structures,physical and chemical properties of the copolymers responded to change,when they were stimulated by external environment. According to the different response mechanism and types of external stimuli,the stimulus-responsive block copolymers were classified into three categories： single stimulus response,dual stimulus response and triple stimulus response. As for each type of system,this review discussed the design,synthesis,self-assembly and application of stimuli-responsive polymers in aqueous solution. Meanwhile,the various ordered aggregates（ such as micelles,vesicles,etc.） changed with stimulus response（ pH,temperature,light,CO_2,redox agent,etc.） were summarized in brief. Finally,the potential application value of intelligent block copolymers in drug controlled release,the synthesis of nano container,biological functional materials and the possible development direction in the future were prospected.

关 键 词：嵌段共聚物 环境响应性 自组装 胶束 药物控释 

分 类 号：O631[理学—高分子化学]