腧穴热敏化艾灸联合雾化吸入喘可治治疗支气管哮喘的临床研究  

Clinical Study of Acupoints Moxibustion combined with Aerosol Inhalation in Treating Bronchial Asthma

作　　者：罗秋燕[1] 张书平[1] 陈永华[1] 

机构地区：[1]成都军区机关医院,四川成都610017

出　　处：《中医药导报》2017年第18期98-101,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨腧穴热敏化艾灸联合雾化吸入喘可治治疗支气管哮喘的临床效果。方法:选取60例支气管哮喘患者,按照随机数字表法分为治疗组与对照组各30例。对照组给予雾化吸入喘可治注射液治疗,治疗组在此基础上联合腧穴热敏化艾灸治疗,两组均持续治疗1个月。疗程结束后统计对比两组临床疗效、入院时及疗程结束后两组哮喘症状评分(ACT评分)、肺功能指标[用力肺活量(FVC)、1 s用力呼气容积(FEV1)、峰值呼气流速(PEF)]及基质金属蛋白酶-9(MMP-9)和组织基质金属蛋白酶抑制剂-1(TIMP-1)水平变化情况。结果:治疗组总有效率为83.3%,对照组为67.3%,差异有统计学意义(P<0.05);治疗组治疗前ACT各项评分与对照组间无明显差异(P>0.05),治疗后,治疗组ACT各项评分明显高于对照组,差异有统计学意义(P<0.05);治疗组治疗前肺功能指标与对照组间无明显差异(P>0.05),治疗后,治疗组FVC、FEV1和PEF均明显高于对照组,差异有统计学意义(P<0.05);治疗组治疗前血清MMP-9、TIMP-1水平与对照组间无明显差异(P>0.05),治疗后,治疗组血清MMP-9、TIMP-1水平均明显低于对照组,差异有统计学意义(P<0.05)。结论:腧穴热敏化艾灸联合雾化吸入喘可治治疗支气管哮喘,可有效改善患者血清MMP-9、TIMP-1水平,从而缓解患者临床症状,提高患者肺功能。Objective： To investigate the clinical effect of acupoint moxibustion with thermosensitive moxibustion combined with aerosol inhalation on bronchial asthma. Methods： The 60 patients with bronchial asthma in our hospital were randomly divided into treatment group and control group, with 30 cases in each group. The control group was given the treatment of atomized inhalation of Chuankezhi. Based on this, the treatment group was treated with acupoint moxibustion. The two groups were treated for 1 month. After the course of treatment, the clinical efficacy of two groups, the scores of asthma symptoms, the indexes of pulmonary function and the changes of matrix metalloprotein-9 （MMP-9） and tissue inhibitor of metalloproteinase-1 （TIMP-1） levels in two groups at the time of admission and the course of treatment were compared. Results： The total effective rate of the treatment group was 83.3%, and the total effective rate of the control group was 67.3%, which the differ- ence was statistically significant （P〈0.05）. The ACT scores between the two groups before treatment had no significant difference （P〉0.05）. After treatment, the ACT scores of the treatment group were significantly higher than that of the control group, and the difference was statistically significant （P〈0.05）. The pulmonary function indexes between the two groups before treatment had no significant difference （P〉0.05）. After treatment, the FVC, FEV1 and PEF index of the treatment group were significantly higher than that of the control group, and the difference was statistically significant （P〈0.05）. The content of serum MMP-9 and TIMP-1 levels between the two groups before treatment had no significant difference （P〉0.05）. After treatment, the content of serum MMP-9, TIMP-1 level of the observation group were significantly lower than those of the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Acupoint moxibustion combined with Chuankezhi atomization inhalati

关 键 词：支气管哮喘 腧穴热敏化艾灸 雾化吸入 喘可治 气道重塑 FVC FEV1 PEF 

分 类 号：R256.1[医药卫生—中医内科学]