白介素-2和白介素-2受体的调控在自身免疫性疾病和器官移植中的作用  

The role of IL-2 and IL-2 recepter in autoimmune diseases and organ transplant

作　　者：黄逸婷 张梅[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029

出　　处：《免疫学杂志》2017年第10期911-915,共5页Immunological Journal

基　　金：国家自然科学基金(81670756;81370939)

摘　　要：白介素-2(interleukin-2,IL-2)是最早发现并应用于临床的细胞因子之一。最初IL-2因具有刺激T细胞增殖的能力引人关注,随后更多研究发现IL-2主要通过结合IL-2受体(interleukin-2 recepter,IL-2R)激活下游信号通路改变调节性T细胞(regulatory T cells,Tregs)与效应性T细胞(effector T cells,Teffs)间的比例,维持免疫耐受,实现人为调节免疫介导疾病的过程。近年来,IL-2在自身免疫性疾病、肿瘤免疫及器官移植耐受诱导中具有广泛的应用前景而备受瞩目。本文主要对IL-2和IL-2受体、其信号传导通路及免疫治疗作用做一综述。IL-2 is one of the earliest cytokines discovered and applied in clinical medicine. At the first time,IL-2 drew much attention because of its ability to stimulate the proliferation of T cells. Posterior studies revealedthat IL-2 can shift the balance between Tregs and Teffs by activating downstream signaling through the combinationwith receptor IL-2R. The shifted balance of Tregs and Teffs could maintain the immune tolerance and thus changethe course of immune-mediated diseases. Recently, with further research on biological activity of IL-2, scientistsre-evaluate the indications, application dose, security, as well as immunotherapeutic effect of IL-2.

关 键 词：白介素-2 调节性T细胞 自身免疫 移植免疫 

分 类 号：R392[医药卫生—免疫学]