烟嘧磺隆中间体2-氯-N,N-二甲基烟酰胺合成新方法  

Novel Synthesis Method of 2-Chloro-N,N-dimethylnicotinamide as an Intermediate of Nicosulfuron

作　　者：钟劲松 薛谊 王文魁 徐强 蒋剑华 

机构地区：[1]南京红太阳生物化学有限责任公司,南京210047

出　　处：《现代农药》2017年第5期20-21,共2页MODERN AGROCHEMICALS

摘　　要：报道了制备烟嘧磺隆中间体2-氯-N,N-二甲基烟酰胺的新方法。以2-氯-3-三氯甲基吡啶为原料,在90~100℃条件下,滴加二甲胺水溶液,控制反应液p H值为8~9,经1步反应合成2-氯-N,N-二甲基烟酰胺。产品质量分数在99%以上,反应收率达到98.5%。该制备工艺反应条件温和,操作简单,适合工业化生产。A novel synthesis method of 2-chloro-N,N-dimethylnicotinamide had been studied by using 2-chloro-3-trichloromethylpyridine as starting material. Aqueous solution of dimethylamine was added dropwise to the solution of 2-chloro-3-trichloromethylpyridine in water, while controlling the temperature between 90-100℃, and the p H value at 8-9.The purity of 2-chloro-N,N-dimethylnicotinamide was above 99%, the yield reached 98.5%. The process was very convenient for operation and suitable for industrial development.

关 键 词：2-氯-N N-二甲基烟酰胺 烟嘧磺隆 2-氯-3-三氯甲基吡啶 合成 新方法 

分 类 号：TQ457.2[化学工程—农药化工]