性别因素导致的机体不同免疫能力对流感病毒致病性的影响  

The Impact of Sex on Influenza Virus Pathogenesis in Humans

作　　者：车茜[1] 周琦[1] 汪良枢[1] 刘以农[1] CHE Qian ZHOU Qi WANG Liangshu LIU Yinong(Sichuan Center for Disease Control and Prevention, Chengdu 610041, Sichuan Province, China.)

机构地区：[1]四川省疾病预防控制中心,成都610041

出　　处：《寄生虫病与感染性疾病》2017年第3期166-168,共3页Parasitoses and Infectious Diseases

摘　　要：女性在病毒、细菌等病原生物感染后能产生较强的天然和获得性免疫。但也更容易发生自身免疫性疾病。流感是由流感病毒引起的急性呼吸道疾病,每年在全球范围内引起300~500万重症感染病例,导致25~50万死亡病例。年龄和基础性疾病本普遍被认为是与疾病严重程度相关的危险因素。但关于性别与疾病的相关性研究还较为有限。了解性别对流感易感性以及严重程度的关系有利于流感的科学防控,如推荐易感人群进行疫苗优先接种等。本文对性别与流感感染及严重程度的相互关系和可能的机制进行了综述。Previous studies have and males in parasitic, fungal improved that the clinical development bacterial and viral infections. Females and outcomes varied between females tend to generate higher innate and a- daptive immune responses, which may be advantageous upon pathogen encounter, but also come at the ex- pense of a higher risk of autoimmune diseases. Influenza is an acute respiratory infection caused by seasonal or avian influenza viruses that circulate worldwide. Annual epidemics of seasonal influenza are estimated to result in about 3 to 5 million cases of severe illness, and about 250 000 to 500 000 deaths globally. Ages and condi- tion diseases are associated with severity of influenza infections. However, knowledge on the impact of sex or gender in the severity of influenza virus and its potential mechanism are still very limited. Understanding the role of sex in human influenza infections will benefit in disease prevention and control, such as target high - risk population in influenza infections for vaccination. Recent studies regarding the association between sex and seasonal or avian influenza infections were reviewed in this study.

关 键 词：流感 性别 发病机制 严重程度 

分 类 号：R511.7[医药卫生—内科学]