藏药八味秦皮丸含朱砂与否对小鼠镇痛抗炎药效作用的影响  

Effect of Baweiqinpi pill with or without cinnabar on analgesic and anti-inflammatory functions in mice

作　　者：王颖 李颖晨 李蕾 王兴达 韩泳平 

机构地区：[1]西南民族大学药学院,四川成都610041

出　　处：《西南民族大学学报（自然科学版）》2017年第5期500-503,共4页Journal of Southwest Minzu University(Natural Science Edition)

基　　金：国家十二五科技支撑计划(2012BAI27B07);研究生创新项目(CX2017SZ083)

摘　　要：目的:探讨藏药八味秦皮丸含朱砂与否对镇痛抗炎药效作用的影响.方法:分别建立冰醋酸致小鼠扭体反应疼痛模型和福尔马林致小鼠炎性疼痛模型,角叉菜胶致小鼠足肿胀急性炎症模型和琼脂致小鼠慢性肉芽肿炎症模型,观察朱砂在八味秦皮丸方中拆掉与否对整体抗炎镇痛药效的影响.结果:八味秦皮丸去/含朱砂与否均能明显或部分减少冰醋酸致小鼠的扭体反应次数,延长其潜伏期,减轻福尔马林诱导小鼠的Ⅱ相舔后足反应,显示出较好的镇痛作用;同时,药物对角叉菜胶诱导的足肿胀反应也能明显或部分缓解,抑制其肿胀程度,对慢性炎症棉球肉芽肿的质量也能明显减轻,显示出较好的抗炎作用.上述作用尤以含朱砂的八味秦皮丸完整方作用最强.结论:含朱砂的八味秦皮丸具有更明显的镇痛抗炎作用,朱砂不能随意舍弃.Objective ：To compare the effect of analgesic and anti-inflammatory between Baweiqinpi pills containing and without cinnabar. Methods： The three experimental models of pain and inflammation were used to observe the pharmacodynamic effects, which can provide scientific basis to decide whether cinnabar could be discarded from Baweiqinpi pills, including： （ 1 ） writhe re- action induced by acetic acid mice, （ 2 ） paw edema caused by carrageenan in mice, （ 3 ） granuloma caused by agar in mice. Results： Baweiqinpi pills containing and not containing cinnabar could reduce the number of writhing response induced by acetic acid markedly or partly, extend incubation period;and significant analgesic and anti-inflammatory effects had also been showed by the reaction of licking back paws for mice induced by formalin and response to the foot swelling induced by carrageen separately, in which it was showed that the effect of Baweiqinpi pills with cinnabar was stronger than that without cinnabar. Conclusion： Baweiqinpi pills with cinnabar has certain analgesic and anti-inflammatory effects, but cinnabar cannot be discarded arbitrarily.

关 键 词：八味秦皮丸 朱砂 抗炎 镇痛 药效比较 

分 类 号：R28[医药卫生—中药学] R29[医药卫生—中医学]