七氟醚、异丙酚全身麻醉对老年患者术后苏醒和认知功能的影响  

Effects of general anesthesia with sevoflurane and propofol on postoperative recovery and cognitive function in elderly patients

作　　者：卢斌 傅强[2] 张庆华 刘俊乐[4] 

机构地区：[1]西安长安区医院麻醉科,陕西西安710100 [2]解放军总医院麻醉手术中心,北京100853 [3]西安市高新医院麻醉科,陕西西安710075 [4]福建医科大学附属协和医院麻醉科,福建福州350001

出　　处：《临床医学研究与实践》2017年第27期42-43,共2页Clinical Research and Practice

摘　　要：目的分析七氟醚、异丙酚全身麻醉对老年患者术后苏醒和认知功能的影响。方法选取我院2014年2月至2016年8月收治的160例行全身麻醉手术的老年患者,随机分为试验组与对照组,每组80例。试验组患者进行异丙酚全身麻醉,对照组患者进行七氟醚全身麻醉,比较两组患者手术后的认知功能情况和苏醒情况。结果试验组患者的清醒时间、睁眼时间和拔管时间均显著短于对照组,差异具有统计学意义(P<0.05);手术后2、6 h,试验组患者的MMSE评分显著高于对照组,差异具有统计学意义(P<0.05);手术后1 d,试验组与对照组患者的MMSE评分比较,差异不具有统计学意义(P>0.05),且术后1d,两组患者的MMSE评分均已基本恢复至术前。结论与七氟醚全身麻醉相比,异丙酚全身麻醉对老年患者术后认知功能的影响较小,患者术后苏醒快,具有临床进一步推广和应用的意义。Objective To study the effect of general anesthesia with sevoflurane and propofol on postoperative recovery and cognitive function in elderly patients. Methods One hundred and sixty cases of elderly patients underwent general anesthesia operation in our hospital from February 2014 to August 2016 were randomly divided into experimental group and control group, with 80 cases in each group. Patients in the experimental group were given propofol anesthesia, and patients in the control group were given sevoflurane anesthesia, the cognitive function and recovery situation of the two groups after surgery were compared. Results The waking time, eye opening time and extubation time of the experimental group were significantly shorter than those of the control group, the differences were statistically significant （P〈0.05）. At 2 and 6 h after operation, the MMSE score of the experimental group were significantly higher than those of the control group, the differences were statistically significant （P〈0.05）; at 1 d after operation, there was no statistically significant difference in the MMSE scores between the two groups （P〉0.05）, and the MMSE scores of the patients in the two groups were basically restored to the preoperative level. Conclusion Compared with sevoflurane general anesthesia, the effect of general anesthesia with propofol on postoperative cognitive function in elderly patients is smaller, and the patients recover quickly after operation. It is worthy of further popularization and application

关 键 词：七氟醚 异丙酚 苏醒 认知功能 全身麻醉 

分 类 号：R614[医药卫生—麻醉学]