2005-2009年中国肿瘤登记地区肝癌疾病负担变化趋势分析  

Trends of disease burden of liver cancer in Chinese cancer registries,2005-2009

作　　者：姜楠[1] 李述刚[1] 闫贻忠 张学飞[1] 张凯丽 赵瑞[1] 王彦镔 郝豪[1] 

机构地区：[1]石河子大学医学院预防医学系,新疆石河子832000

出　　处：《现代预防医学》2017年第19期3483-3487,3507,共6页Modern Preventive Medicine

基　　金：新疆兵团石河子肿瘤登记与食管癌/贲门癌早诊早治项目(兵财社[2011]141号)

摘　　要：目的分析2005-2009年中国肿瘤登记地区肝癌疾病负担的变化趋势,为评价肝癌防治措施和制定防治策略提供科学依据。方法根据肿瘤登记年报肝癌相关发病死亡数据,计算每千人潜在减寿年(PYLL率)、标化每千人潜在减寿年(s PYLL率)、每千人伤残调整寿命年(DALY率)、相对比(RR)等指标连续性分析我国2005-2009年肝癌疾病负担的变化趋势。结果 2005-2009年全国肿瘤登记地区肝癌新发病例为90047例,发病率为27.63/10万;死亡病例为83976例,死亡率为25.77/10万。PYLL率(2.56/千人~2.65/千人)和DALY率(3.19/千人~3.30/千人)均维持在稳定水平。其中城镇地区疾病负担呈上升趋势,PYLL率和DALY率分别上升了9%和7%;农村地区疾病负担呈下降趋势,PYLL率和DALY率分别下降了22%和14%。农村与城镇发病率之比由1.45下降至1.24,死亡率之比由1.52下降至1.24,PYLL率之比由2.02下降至1.43,DALY率之比由1.73下降至1.39。肝癌的死亡发病比在2006年达峰值0.97,随后逐年下降。结论 2005-2009年我国肿瘤登记地区肝癌疾病负担仍较重,男性高于女性,农村高于城镇。农村与城镇肝癌疾病负担的差距正在缩小。Objective The study aimed to analyze the trends of the disease burden of liver cancer in Chinese cancer registries from 2005 to 2009, so as to provide a scientific basis for evaluating measures and making strategy on its prevention and control. Methods We Collected data from Chinese cancer registry annual report, and calculated potential years of life lost rate （ PYLL rate）, standardized potential years of life lost rate （PYLL rate）, disability -adjusted life years rate （DALY rate ）, relative ratio （RR） and other indexes of liver cancer to analyze the trends of its disease burden from 2005 to 2009 continuously. Results The total incident cases and deaths of liver cancer in the registration areas in 2005 - 2009 were 90,047 and 83,976, respectively with the incidence of 27.63 per 100000 and mortality of 25.77 per 100000. PYLL rates （2.56 per 1000 to 2.65 per 1000） and DALY rates （3.19 per 1000 to 3.30 per 1000） remained stable. But the disease burden of liver cancer in urban areas showed an upward trend, PYLL rates and DALY rates increased by 9% and 7% respectively. By contrast, the disease burden in rural areas showed a downward trend,and PYLL rates and DALY rates decreased by 22% and 14% respectively. The rural to urban ratios of incidence and mortality decreased from 1.45 to 1. 24 and from 1.52 to 1.24 respectively. The rural to urban ratios of PYLL rates and DALY rates decreased from 2.02 to 1.43 and from 1.73 to 1.39 respectively. The mortality to incidence ratio of liver cancer has reached the peak 0.97 in 2006 and then decreased. Conclusion The burden caused by liver cancer in Chinese cancer registries in 2005 - 2009 was still heavy, particularly for men and rural areas. But the gap of the disease burden of liver cancer between rural and urban areas is narrowing.

关 键 词：肝癌 疾病负担 PYLL率 DALY率 

分 类 号：R181.23[医药卫生—流行病学]