帕金森病合并抑郁与血清细胞因子的相关研究  

The role of inflammatory cytokines in patients with depression in Parkinson′s disease

作　　者：欧阳樱君[1] 吴爱武 余健敏[1] 张惠丽[1] 戴卉[1] 

机构地区：[1]广州医科大学附属广州市第一人民医院神经内科,广州市510180 [2]广州医科大学金域检验学院,广州市510182

出　　处：《实用医学杂志》2017年第19期3255-3260,共6页The Journal of Practical Medicine

基　　金：广东省科技厅项目(编号:2013B021800062);广州市医药卫生科技项目(编号:20161A011002)

摘　　要：目的检测帕金森病合并抑郁(DPD)、帕金森病(PD)及抑郁症(DD)的血清免疫细胞因子的变化,探讨DPD的细胞因子其变化的相关因素。方法应用酶联免疫吸附法检测77例患者(22例DPD,33例PD,22例DD)及23例健康志愿者其血清IL-6、IL-18和TNF-α水平,并对DPD患者进行相关量表评估。结果 DPD、PD及DD患者外周血清中IL-6和TNF-α均较正常人显著降低,IL-18未见变化;DPD患者经抗抑郁治疗后,其IL-6及TNF-α水平显著升高,但IL-18未见变化;细胞因子水平在DPD患者性别和抑郁严重程度不同中无差异;同时细胞因子水平的变化与DPD的UPDRS-Ⅲ、H&Y分期、MMSE以及HAMD-24评分不相关。结论外周血清中TNF-α和IL-6水平降低可能是DPD的早期预测指标之一,但外周血清IL-18的作用暂不能肯定。Objective To compare the serum levels of interleukin （IL）-6, IL-18 and tumor necrosis factor alpha（TNF-α） in patients with DPD, PD, depression disorder and healthy controls and to analyze the conclations of serum inflammatory factors in DPD patients. Methods Serum levels of IL-6, IL-18 and TNF-α were measured using enzyme linked immunosorbent assay （ELISA） kits. Several scales were performedin DPD patients. Results DPD, PD and depression disorder patients had significant lower baseline levels of IL-6 and TNF-α when compared to healthy controls （P 〈 0.05）. The levels of IL-6 and TNF-α in DPD patients were significantly increased after 4 weeks of anti-depression treatment （P 〈 0.05）. No difference of cytokines levels in gender and in severity of DPD patients was detected Serum levels of these inflammatory cytokines were not significantly correlated with the UP- DRS Ⅲ , H ＆ Y, MMSE and HAMD scores in DPD patients. Conclusions Serum inflammatory factors （IL-6, TNF-α） were altered in patients with DPD in the earlier course of disease. However, the role of IL-18 remained unknownin the occurrence of DPD disease.

关 键 词：帕金森病 抑郁症 帕金森病合并抑郁 IL-6 IL-18 TNF-Α 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]