ECM支架与软骨修复  

ECM Scaffold and Cartilage Reparation

作　　者：付晶[1,2] 褚文辉[1] 张伟[1] 张爱武[2] 马丽娟[2] 李春义[1] 

机构地区：[1]中国农业科学院特产研究所,长春130112 [2]吉林农业大学中药材学院,长春130118

出　　处：《基因组学与应用生物学》2017年第9期3662-3667,共6页Genomics and Applied Biology

基　　金：吉林省科技发展计划项目(20140204010YY)资助

摘　　要：细胞外基质(extracellular matrix,ECM)支架是含有很多生物活性分子的天然生物材料,可以维持组织内稳态并诱导组织再生。ECM支架最大的优势是其可降解,且不会引起免疫排斥。目前,临床应用中ECM支架已经成功用于心血管、软骨组织等重建。软骨组织工程中,利用ECM支架进行修复的软骨组织具有结构稳定,低免疫原性,生物可降解及天然成分保留完整等优势特点。本综述回顾了ECM支架的来源、制备方案,评述了其在软骨组织修复中的优势与前景,有助于ECM支架在未来更好地应用。Extracellular Matrix（ECM） scaffold is a natural biological material that contain a lot of bioactive molecules.It can maintain the homeostasis of tissues and induce their regeneration.The biggest advantage of ECM scaffold is biodegradable,and it won＇t cause immune rejection.At present,ECM scaffold has been successfully used in the reestablishment of cardiovascular and cartilage tissue in clinic.The cartilage tissue repaired by using ECM scaffold has some advantageous features,such as its stable structure,low immunogenicity,biodegradable property,and its complete reservation of natural ingredients.This paper reviewed the source and preparation solution of ECM scaffold,and observed the advantages and prospect of cartilage reparation.It would contribute to the better application of ECM scaffold in the future.

关 键 词：细胞外基质 支架 软骨修复 

分 类 号：R318.08[医药卫生—生物医学工程]