白细胞介素-35在感染性疾病中的作用及意义  

Important role of interleukin-35 in infectious diseases and its significance

作　　者：姚人骐 吴瑶[2] 马兵[3] Yao Renqi Wu Yao Ma Bing(Second Military Medical University, Shanghai 200433, Chin Trauma Research Center, First Hospital Affiliated to Chinese PLA General Hospital, Beijing 100048, Chin Burn and Trauma Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)

机构地区：[1]第二军医大学学员旅,上海200433 [2]解放军总医院第一附属医院创伤研究中心,北京100048 [3]第二军医大学长海医院烧创伤中心,上海200433

出　　处：《中华危重病急救医学》2017年第9期848-852,共5页Chinese Critical Care Medicine

基　　金：国家自然科学基金（81372054,81130035）

摘　　要：感染性疾病是由多种致病微生物侵入机体组织而引起的一类疾病,其发生发展与机体免疫功能状态有关.细胞因子在介导机体针对病原微生物的免疫反应及维持机体免疫稳态等过程中具有重要作用.白细胞介素-35（IL-35）作为一种新的细胞因子,属于IL-12家族,主要通过特异性作用方式发挥对机体免疫效应的抑制功能.有资料证实,IL-35在多种感染性疾病的免疫发病机制中扮演重要角色,并与疾病的严重程度、病情进展及患者预后密切相关,包括乙型肝炎、脓毒症、结核病及寄生虫感染等.因此,IL-35作为一种强有力的抗炎细胞因子日益受到关注,其潜在的应用价值有望为感染性疾病的防治提供新思路.本文主要对IL-35在感染性疾病中作用及意义的研究进展进行综述.Infectious diseases are resulted from the invasion of an organism＇s body tissues by multiple disease-causing agents. It has been demonstrated that the occurrence and development of infectious diseases are closely associated with the functional status of immune system. Cytokines play significant roles in modulating the host immune response to the clearance of pathogenic microorganisms and maintaining immune homeostasis. Interleukin-35 （IL-35）, as a newly identified member of IL-12 family, exerts suppressive effect on immune response by means of a specific pattern. With the progress of research in recent years, IL-35 might serve as an essential contributor in the immunopathogensis of vast infectious diseases, including hepatitis B, sepsis, tuberculosis and parasite infection, which simultaneously appear to be closely related to the severity, progression as well as prognosis of the illness. Apparently, IL-35 is regarded as a potent and promising anti-inflammatory cytokine in clinical application; its potential value may shed light on the therapeutic strategies for infectious diseases. Herein, we mainly review the potential role and its mechanism of IL-35 in the pathogenesis of infectious diseases.

关 键 词：感染性疾病 白细胞介素-35 脓毒症 

分 类 号：R51[医药卫生—内科学]