高原环境对人外周血细胞的影响  

Effects of high altitude environment on human peripheral blood cells

作　　者：肖军 李小薇[1] 雷慧芬[1] 祁术元[1] 魏少平[1] 王洪波[1] 李翠莹[1] 甘新宇[2] 黄菲[2] 杨俊龙 

机构地区：[1]空军总医院输血科,北京100142 [2]成都军区总医院输血科

出　　处：《中国输血杂志》2017年第8期870-872,共3页Chinese Journal of Blood Transfusion

基　　金：全军后勤科研重大专项子项(AWS13J004)

摘　　要：目的研究在进入高原前后人外周血血细胞的变化,分析高原环境对人血细胞的影响。方法通过比较在平原和高原习服(90 d)后的血细胞,分析高原环境对个体血细胞的影响。结果高原习服后红细胞、血红蛋白、红细胞压积、平均红细胞容积均明显升高(P<0.01),而平均血红蛋白浓度和平均血红蛋白含量出现下降(P<0.01);进入高原90 d后白细胞计数无明显变化,而淋巴细胞计数和单核细胞计数均有升高(P<0.01),中性粒细胞计数下降(P<0.01);高原习服后血小板计数显著升高(P<0.01),而血小板体积分布宽度和平均血小板体积则有所下降(P<0.01)。结论高原习服后血细胞红系、淋巴细胞、单核细胞、血小板指标代偿性升高,以满足机体对高原低氧环境的适应。Objective To analyze human peripheral blood cells before and after entering the plateau in an effort to iden- tify changes beween the two stayes, which should provide valuable data to evaluate the effect of high altitude environment on human blood cells. Methods The effect of high altitude environment on individual peripheral blood ceils were analyzed by comparing the peripheral blood cells pre and post entering the plateau area. Results The RBC, Hb, Hct, MCV were signif- icantly increased after the acclimatization （P〈0. 01） , but the MCHC and the MCH decreased （P〈0. 01） ; There was no sig- nificant change in white blood cell count after the acclimatization at the plateau, but the number of lymphocytes and mononu- clear cells increased （P〈0. 01 ） , and the number of neutrophils decreased（ P〈0. 01 ） ; The Pit count increased significantly after the acclimatization （P〈0. 01 ）, but the platelet volume distribution width and mean platelet volume decreased （P〈 0. 01 ）. Conclusion The red blood cell line, lymphocytes, monocytes and platelets were compensated for the adaption to the hypoxic environment at high altitude.

关 键 词：低压低氧 外周血 血常规检查 高原环境 

分 类 号：R331.14[医药卫生—人体生理学] R135.6[医药卫生—基础医学]