航空运输对红细胞能量代谢及携氧能力的影响  

Effect of air transport on RBC energy metabolism and oxygen delivering capacity

作　　者：刘家玉[1] 卓海龙[1] 邵春燕[1] 赵丽坤 赵晨君[1] 张菁 骆群[1] 甘新宇[2] 于丽君[2] 李翠莹[3] 

机构地区：[1]军事医学科学院附属医院输血科,北京100071 [2]成都军区总医院输血科 [3]空军总医院输血科

出　　处：《中国输血杂志》2017年第8期874-876,共3页Chinese Journal of Blood Transfusion

基　　金：全军后勤科研重大专项子项(AWS13J004)

摘　　要：目的观察航空运输对悬浮红细胞能量代谢及携氧能力的影响。方法于成都采集并制备悬浮红细胞30袋(2 U/袋),每袋无菌技术分离出100 m L置于4℃冰箱作为对照组,实验组成都至拉萨空运往返,在特定保存时间检测两组悬浮红细胞中的乳酸、葡萄糖、K^+、Na^+、PaO_2、PaCO_2、2,3-DPG的含量。结果实验组红细胞中K^+(20.00±0.00)mmol/L和PaCO_2(109.9±8.15)mm Hg均高于对照组K^+(19.78±0.48)mmol/L和Pa CO2(85.33±24.86)mm Hg,且差异均具有统计学意义(P<0.05);实验组红细胞中葡萄糖(21.68±3.00)mmol/L和PaO_2(47.97±17.37)mm Hg均低于对照组葡萄糖(22.30±2.40)mmol/L和PaO_2(117.4±79.62)mm Hg,且差异均具有统计学意义(P<0.05);实验组与对照组相比,Na+、2,3-DPG含量的差异无统计学意义(P>0.05)。结论航空运输会对红细胞能量代谢及携氧能力,尤其是K^+和乳酸含量有影响。Abstract： Objective To observe the effect of air transport on energy metabolism and oxygen delivering capacity of red blood cells suspensions. Methods We collected and prepared 30 bags of red blood cells suspensions in Chengdu, then 100 mL were separated from each bags using aseptic technologie, leaved those separated bags in Chengdu and preserved in refrig- erator at 4℃ as control group. Others were transported to Lhasa then back to Chengdu by air, as treatment group. The con- centration of lactic acid, glucose, K^＋, Na^＋, PaO2, PaCO2,2,3-DPG in red blood cells suspension were detected at different time during the shelf life of the RBCs. Results The mean level of K^＋（ 20.00±0.00） mmol/L and PaCO2（ 109.9±8. 15 ） mm- Hg in treatment group were higher than K^＋（ 19.78±0. 48 ） mmol/L and PaCO2 （ 85.33± 24. 86 ） mmHg in control group. The mean level of glucose （ 21.68±3.00） mmol/L and PaO2 （ 47.97 ±17.37 ） mmHg in treatment group were lower than glucose （22. 30±2. 40）mmol/L and PaO2（ 117.4±79.62 ）mmHg in control group. There was a significant difference （P〈 0. 05 ） at the value of glucose, K^＋ , PaO2, PaCO2, no significant difference （P〉0. 05 ）emerged in the value of Na＋ and 2,3-DPG.Conclusion Air transport could impact the energy metabolism and oxygen delivering capacity of red blood cells.

关 键 词：航空运输 红细胞能量代谢 红细胞携氧能力 

分 类 号：R331.141[医药卫生—人体生理学] U8[医药卫生—基础医学]