四角蛤蜊壳制备L-天门冬氨酸螯合钙工艺及表征研究  

Synthesis and characterization of amino acid chelated calcium with shells as primary calcium source

作　　者：王青[1] 刘睿[1] 程建明[1] 王欣之[1] 吴皓[1] 彭九嫚 杜俊潮 倪骏[1] WANG Qing LIU Rui CHENG Jian-ming WANG Xin-zhi WU Hao PENG Jiu-man DU Jun-chao NI Jun(Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceuties, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medieine,Nanjing 210023, China)

机构地区：[1]南京中医药大学江苏省海洋药用生物资源研究与开发重点实验室,江苏省中药资源产业化过程协同创新中心,江苏南京210023

出　　处：《中国海洋药物》2017年第4期87-94,共8页Chinese Journal of Marine Drugs

基　　金：国家海洋局海洋公益性行业专项(201305007,201405017);国家高新技术研究发展计划项目(2013AA093003);江苏高校优势学科建设项目(PAPD);江苏省“青蓝工程”;江苏省“333工程”资助

摘　　要：目的以废弃物四角蛤蜊贝壳为钙源,经过中药煅法炮制后,与L-天门冬氨酸制备氨基酸螯合钙。方法以得率和螯合率为指标综合评分考查L-天门冬氨酸与四角蛤蜊贝壳的螯合工艺并进行优化,且通过红外和差示扫描量热仪等对其产物进行组成表征研究。结果确定L-天门冬氨酸螯合钙的最佳螯合工艺:pH=5.0,反应温度为65℃,反应时间为1.5h,摩尔比(氨基酸∶Ca2+)为2∶1,且初步研究发现结构为带2个结晶水的螯环结构。结论 L-天门冬氨酸螯合钙的制备,能有效利用贝壳废弃物,补充人体钙元素和基本氨基酸,为L-天门冬氨酸螯合钙的工业生产提供理论基础。Objective As the source of calcium, the shells were processed by calcining openly to prepare a- mino acid chelated calcium with L-aspartic acid. Methods The yielding results and chelation ratio were used to evaluate the chelation procedures, meanwhile the product was qualitatively identified by infrared and differential scanning calorimetry. Results Optimum chelation procedure was as following, pH= 5.0, reaction temperature 65 ℃, reaction time 1.5 h, the molar ratio of （Ca2＋ ： amino acid） as 2 ： 1. And preliminary study found the structure had two crystal water molecules. Conclusion The preparation of L- aspartate calcium could effectively use shell waste and provide a theoretical basis for the industrial production of L- aspartate chelating calcium.

关 键 词：氨基酸螯合钙 L-天门冬氨酸 螯合工艺 结构表征 

分 类 号：R915[医药卫生—微生物与生化药学]