中药对线粒体功能的影响及其药理作用研究进展  

Progress on the Studies of Effect of Traditional Chinese Medicines on Mitochondrial Functions and their Pharmacologic Actions

作　　者：杨兴鑫[1,2,3] 徐风 俞捷[3] 周瑜珍[1] 杨志伟 王义 尚明英 王璇[1] Yang XingXin Xu Feng Yu Jie Zhou YuZhen Yang ZhiWei Wang Yi Shang MingYing Wang Xuan(Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191 College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650500)

机构地区：[1]北京大学药学院化学生物学系,北京100191 [2]北京大学药学院天然药物与仿生药物国家重点实验室,北京100191 [3]云南中医学院中药学院药物分析教研室,昆明650500

出　　处：《生命科学仪器》2017年第4期15-21,共7页Life Science Instruments

基　　金：高等学校博士学科点专项科研基金(20130001110057);国家自然科学基金(81660596);云南省应用基础研究计划项目青年项目(2016FD050);云南省中青年学术和技术带头人后备人才(2015HB053)

摘　　要：中药药效评价及作用机制研究是阐释中药药效本质,实现中药现代化的关键,线粒体作为细胞"发动机",参与生物体内多项重要生理和生化过程的调节,通过探究中药对线粒体结构、功能的影响,可有效地评价中药药效,并探索其作用机制。研究表明,许多中药均可通过影响线粒体功能而发挥各种疾病治疗作用,本文将对中药通过影响线粒体功能而发挥的药理作用及机制进行简要综述,并提出当前研究存在的主要问题及对策,同时给予展望。The studies of efficacy and action mechanism of traditional Chinese medicines （TCMs） are important for elucidating the pharmacodynamic essence of TCMs and realizing the TCM modernization. As the cells＇ ＂engine＂, mitochondria participate in the regulation of many important physiological and biochemical processes in organism. Thus, the efficacy and mechanism of TCMs can be effectively investigated by exploring the effect of TCMs on mitochondrial structure and functions. The research results indicate that a large number of TCMs could play a role in the treatment of various diseases by affecting the mitochondrial functions. In this review, the efficacy and mechanism of TCMs through affecting the mitochondrial functions will be briefly summarized. Furthermore, the main problems and their countermeasures of current research relating to the interaction between TCMs and mitochondria will be proposed with the future perspectives.

关 键 词：中药 线粒体 药效评价 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]