Mitochondrial replacement techniques or therapies (MRTs) to improve embryo development and to prevent mitochondrial disease transmission  

作　　者：Xiang-Hong Ou Qing-Yuan Sun Xiang-Hong Ou;Qing-Yuan Sun(Reproductive Medicine Center,The 2nd People's Hospital of Guangdong Province,Guangzhou 510317,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100101,China)

机构地区：[1]Reproductive Medicine Center, The 2nd People＇s Hospital of Guangdong Province, Guangzhou 510317, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing I00101, China [3]University of Chinese Academy of Sciences, Beijing 100101, China

出　　处：《Journal of Genetics and Genomics》2017年第8期371-374,共4页遗传学报（英文版）

摘　　要：The mitochondrion which contains its own double-stranded circular DNA is a semi-independent organelle that plays critical roles in cell activity. Mitochondrial DNA （mtDNA） is maternally inherited through several mechanisms that have been proposed （Luo et al., 2013） and, if mitochondrial mutations are inherited to the offspring, it is possible to cause mitochondrial diseases such as neuropathy, cardiomyopathy, myopathy, and liver failure.The mitochondrion which contains its own double-stranded circular DNA is a semi-independent organelle that plays critical roles in cell activity. Mitochondrial DNA （mtDNA） is maternally inherited through several mechanisms that have been proposed （Luo et al., 2013） and, if mitochondrial mutations are inherited to the offspring, it is possible to cause mitochondrial diseases such as neuropathy, cardiomyopathy, myopathy, and liver failure.

关 键 词：mtDNA Mitochondrial replacement techniques or therapies to improve embryo development and to prevent mitochondrial disease transmission 

分 类 号：R596[医药卫生—内科学]