抗-HCV-IgG抗体以及血清HCV-RNA在丙型肝炎诊断中的应用价值  

The value of Anti-HCV-IgG antibody and serum HCV-RNA in the diagnosis of hepatitis c

作　　者：徐红梅[1] 张有辉[1] 

机构地区：[1]内江市第一人民医院检验科,四川内江641000

出　　处：《国际检验医学杂志》2017年第18期2549-2550,2553,共3页International Journal of Laboratory Medicine

摘　　要：目的研究抗-HCV-IgG抗体和血清HCV-RNA在丙型肝炎诊断中的应用价值。方法抽选2015年12月至2016年12月76例丙型肝炎患者展开研究,所有患者均进行血清抗-HCV-IgG抗体检测和血清HCV-RNA检测,对比分析两种方法单独检测及联合检测对丙型肝炎的阳性检出率。结果 76份标本抗-HCV-IgG抗体检测阳性率为27.63%,血清HCV-RNA检测阳性率为25.00%,两种联合检测阳性率为22.37%,3种方法阳性率均较接近,但差异无统计学意义(P>0.05)。按照HCVRNA病毒不同载量区间划分,抗-HCV-IgG检测阳性率不断升高,5个区间分别为60.00%、83.33%、100.00%、100.00%、100.00%。结论单一检测抗-HCV-IgG抗体、血清HCV-RNA诊断丙型肝炎均具有局限性,联合检测能够有效降低漏诊率,提高阳性率检出,为临床诊断丙型肝炎提供可靠依据。Objective To study the anti-HCV-IgG antibody and serum HCV-RNA value in the diagnosis of hepatitis c.Methods From December 2015 to December 2006,76 patients with hepatitis C were enrolled in this study.All patients were tested for serum anti-HCV-IgG antibody and serum HCV-RNA,and the positive detection rate of hepatitis C was detected by two methods alone.Results 76 specimens of anti-HCV IgG antibody testing positive rate was 27.63%,the detection of serum HCV-RNA positive rate was 25.00%,the two kinds of joint detection positive rate was 22.37%,the three methods positive rate were relatively close,but there was no significant difference（P0.05）.According to different loads interval differentiate HCV-RNA virus detection rate of rising,anti-HCV-IgG five interval were 60.00%,83.33%,100.00%,100.00%,100.00%.Conclusion The detection of single anti-HCV IgG antibody or serum HCV RNA in the diagnosis of hepatitis c have limitations,the joint detection can effectively reduce the missed diagnosis and improve positive rate and provide a reliable basis for clinical diagnosis of hepatitis C.

关 键 词：抗-HCV-IgG抗体 血清HCV-RNA 丙型肝炎 临床诊断 

分 类 号：R446.6[医药卫生—诊断学] R512.63[医药卫生—临床医学]