虫草素与羟丙基-β-环糊精的包合行为及性能研究  

Study on Inclusion Behavior and Properties of Cordycepin with Hydroxypropyl-β-Cyclodextrin

作　　者：赵芳 赵雪秋 常清 王淑慧 杜瑶 杨丽娟 

机构地区：[1]云南民族大学化学与环境学院,昆明650500 [2]云南民族大学民族药资源化学国家民委一教育部重点实验室,昆明650500

出　　处：《分析化学》2017年第10期1547-1555,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(Nos.21762051,21562048,21162042)项目;云南民族大学创新团队项目资助~~

摘　　要：通过饱和溶液方法制备了虫草素(COR)与羟丙基-β-环糊精(HPβCD)形成的包合物。采用紫外-可见光谱法对水溶液中HPβCD与虫草素(COR)的包合行为进行研究,利用Job曲线法确定COR/HPβCD包合物的包合比,通过~1H NMR和2D NMR、DSC、TG、XRD、FTIR和SEM对COR/HPβCD包合物进行表征和性能测定。结果表明,COR/HPβCD包合物的包合比为1∶1,虫草素与HPβCD形成包合物后,其水溶性、热稳定性及生物环境稳定性都得到明显提高。COR/HPβCD包合物在医药领域具有潜在的应用前景。The inclusion complex of cordycepin（COR） with hydroxypropyl-β-cyclodextrin（HPβCD） was prepared by the method of saturated solution.The inclusion of HPβCD with COR in aqueous solution was studied by UV-vis spectroscopy,and the inclusion ratio of COR/HPβCD complex was determined with the Job plots.The COR/HPβCD complex was characterized and determined by means of ~1H NMR and 2D NMR,differential scanning calorimetry（DSC）,thermogravimetric analysis（TG）,X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR） and scanning electron microscope（SEM）.The results showed that the COR/HPβCD complex ratio was 1∶1 and the water solubility and stability of COR were obviously increased in the inclusion complex with HPβCD.The COR/HPβCD complex will be potentially useful for its medical application.

关 键 词：虫草素 羟丙基-Β-环糊精 包合物 水溶性 稳定性 

分 类 号：TQ460.1[化学工程—制药化工]