滋阴降火法对阴虚内热证系统性红斑狼疮患者细胞因子IL-10、IL-18的影响  

Effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency

作　　者：谢晓辉[1] 杜晨光 丁培杰 徐丁洁 赵姣姣 董玉山 XIE Xiaohui DU Chenguang DING Peijie XU Dingjie ZHAO Jiaojiao DONG Yushan(Preventive Health Section, Tan~iazhuang Hospital of Kailuan Group Limited Liability Company, Tangshan , Hebei , 063100 Department of Traditional Chinese Medicine, TCM College of North China University of Science and Technology, Tangshan , Hebei , 063100)

机构地区：[1]开滦集团(有限)责任公司唐家庄医院预防保健科,河北唐山063100 [2]华北理工大学中医学院中医科,河北唐山063100

出　　处：《实用临床医药杂志》2017年第17期61-63,共3页Journal of Clinical Medicine in Practice

基　　金：河北省中医药管理局项目(2014184);河北省中医药管理局项目(2015160)

摘　　要：目的观察滋阴降火法对阴虚内热证系统性红斑狼疮患者细胞因子白细胞介素-10(IL-10)、白细胞介素-18(IL-18)的影响。方法选取86例阴虚内热证系统性红斑狼疮患者,按随机数表法分为对照组(n=43)和研究组(n=43)。对照组采用常规西医治疗,研究组在对照组基础上采用滋阴降火法治疗。比较2组中医症候积分、细胞因子IL-10、IL-18水平的变化情况及不良反应发生情况,并评价2组临床疗效。结果治疗后,2组细胞因子IL-10、IL-18均显著下降,且研究组下降幅度较对照组更显著(P<0.05)。研究组临床疗效总有效率为95.35%,显著高于对照组69.77%(P<0.05)。研究组不良反应发生率为6.98%,与对照组9.30%相比,差异无统计学意义(P>0.05)。结论对阴虚内热证系统性红斑狼疮患者采用滋阴降火法治疗,可显著提高临床疗效,缓解临床症状,且不会增加不良反应的发生。Objective To observe the effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency. Methods A total of 86 systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency were enrolled and randomly divided into control group and research group,43 cases in each group. The control group was treated with conventional western medicine,while research group was treated with yin-tonifying and fire-removing prescription on basis of control group.The TCM symptom score,serum IL-10 and IL-18 levels and the incidence rate of adverse reactions were compared between the two groups. The clinical efficacy of the two groups was evaluated. Results After treatment,the levels of IL-10 and IL-18 in both group decreased significantly,and the levels in research group were significantly lower than control group（ P〈0. 05）. The total effective rate was95. 35% in research group,which was significantly higher than 69. 77% in the control group（ P〈0. 05）. The incidence rate of adverse reactions was 6. 98% in the research group,whichwas similar to 9. 30% in the control group（ P〉0. 05）. Conclusion For systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency,yin-tonifying and fire-removing prescription can significantly improve the clinical efficacy,alleviate clinical symptoms,and will not increase the incidence rate of adverse reactions.

关 键 词：滋阴降火法 阴虚内热证 系统性红斑狼疮 IL-10 IL-18 

分 类 号：R593.24[医药卫生—内科学]