玻璃体注射康柏西普治疗152例糖尿病黄斑水肿的疗效及安全性  

Efficacy and safety of intravitreal injection of Compaq in the treatment of 152 patients with diabetic macular edema

作　　者：李慧俐[1] 孙雅楠 刘丹 韩新刚 LI Huili SUN Yannan LIU Dan HAN Xingang(Department of Ophthalmology, General Hospital of Pingmei Group in Pingdingshan City of He＇nan Province, Pingdingshan 467000, Chin)

机构地区：[1]河南省平顶山市平煤集团总医院眼科,平顶山467000

出　　处：《上海医药》2017年第19期15-17,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:观察康柏西普针玻璃体注射治疗糖尿病黄斑水肿的疗效及安全性。方法:选择糖尿病黄斑水肿患者152例152眼,根据治疗方法不同分成观察组和对照组各76例76眼。观察组给予康柏西普针玻璃体注射治疗,对照组给予曲安奈德玻璃体注射治疗。观察比较两组治疗前后视力、黄斑中心视网膜厚度和眼压的变化及术后并发症情况。结果:两组治疗后4周、8周、12周各时间点视力均明显高于治疗前,且不同时间点黄斑中心视网膜厚度均较治疗前减少(P<0.05);观察组治疗后不同时间点眼压值无显著变化,对照组治疗后不同时间点眼压值与治疗前相比均显著升高(P<0.05);治疗后观察组眼压升高的发生率低于对照组(P<0.05)。结论:康柏西普针玻璃体注射治疗糖尿病黄斑水肿可明显提高视力,减轻黄斑水肿程度,疗效与曲安奈德玻璃体注射治疗相当,且安全性更好。Objective： To observe the efficacy and safety of intravitreal injection of Compaq in the treatment of diabetic macular edema. Methods： One hundred and fifty-two eyes of 152 patients with diabetic macular edema were divided into an observation group and a control group with 76 eyes each based on different treatment methods. The patients in the observation group were treated with intravitreal injection of compaq while with intravitreal injection of triamcinolone acetonide in the control group. The changes of visual acuity, macular central retinal thickness, intraocular pressure and the complications were observed and compared between the two groups before and after treatment. Results： The visual acuity at each time point of postoperative 4, 8 and 12 weeks was significantly higher and the macular retinal thickness was thinner after treatment than before （P〈0.05）. Intraocular pressure （IOP） in the treatment group at different time points showed no significant changes, however, lOP in the control group at different time points was significantly increased after treatment compared with before （P〈0.05）. The incidence of elevated intraocular pressure was lower in the treatment group than in the control group after treatment （P〈0.05）. Conclusion： The intravitreal injection of Compaq for the treatment of diabetic macular edema can significantly improve the visual acuity and reduce the macular edema. Its curative effect is similar to that of intravitreal injection of triamcinolone acetonide but with higher safetv.

关 键 词：康柏西普针 玻璃体注射 糖尿病黄斑水肿 视力 眼压 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]