八仙逍遥汤药浴对大鼠压力性损伤的预防和治疗效果  

Prevention and treatment effect of baxianxiaoyao decoction medicated bathing on rat pressure injury

作　　者：常淑文 三浦大志 北山秋雄 一志步乃加 梁景岩 陈齐红[5] 束余声[6] 乔炎 Chang Shuwen Miura Daiji Kitayama Akio Isshi Honoka Liang Jingyan Chen Qihong Shu Yusheng Takashi En(School of Nursing, Yangzhou University, Yangzhou 225001, China ICU, Northern Jiangsu People＇s Hospital, Yangzhou 225001, China Department of Basic Medicine and Nosography, Nagano College of Nursing, Komagane, Nagano 399-4117, Japan Department of Health Science, Nagano College of Nursing, Komagane, Nagano 399-4117, Japan Yangzhou Medical College, Yangzhou University, Yangzhou 225001, China Cardiothoracic Surgery, Northern Jiangsu People＇s Hospital, Yangzhou 225001, China)

机构地区：[1]扬州大学护理学院225001 江苏省苏北人民医院ICU,扬州225001 [2]399—4117日本长野县看护大学基础医学·疾病学领域,399411 [3]399—4117日本长野县看护大学健康保健学领域,399411 [4]扬州大学医学院,225001 [5]江苏省苏北人民医院ICU,扬州225001 [6]江苏省苏北人民医院心胸外科,扬州225001

出　　处：《中华现代护理杂志》2017年第21期2714-2720,共7页Chinese Journal of Modern Nursing

基　　金：国家自然科学基金（81670065）;2015年日本长野县特别研究费（特A-③）

摘　　要：目的 观察八仙逍遥汤药浴对大鼠压力性损伤创面的预防和治疗作用.方法 本研究于2016年4月—2017年2月进行.实验经日本长野县看护大学动物实验伦理委员会批准,在日本长野县看护大学基础医学实验室完成.24只大鼠被分成对照组（A组）、温水沐浴组（B组）及中药药浴组（C组）,每组8只.A组不做处理,B组使用温水沐浴,C组采用八仙逍遥汤药浴,入浴2周后建立压力性损伤模型,通过Image-J计算溃疡图像的平均面积、最大-最小浓度差;比较3组间伤口面积、愈合率、创面中心温度和皮肤含水量变化.结果 3组大鼠造模后12 h压力性损伤面积,对照组为（137.060±18.258）mm2,温水组为（123.310±14.969）mm2,中药组为（92.520±11.159）mm2,3组比较差异有统计学意义（F=73.235,P〈0.05）;Image-J测量3组间溃疡图片的平均面积、图像中的最大浓度和最小浓度差,差异均有统计学意义（F值分别为8.13、4.91;P〈0.01）.伤口愈合率在在造模后12 h、4 d、8 d、12 d差异有统计学意义（F值分别是8.058、12.024、17.360、26.006;P〈0.05）,皮肤含水量3组间差异无统计学意义（P〉0.05）.结论 八仙逍遥汤药浴对压力性损伤创面有一定的预防作用,并且能够促进创面的早期愈合.ObjectiveTo study the preventive and therapeutic effects of Baxianxiaoyao decoction medicated bath on pressure injury wound in rats.Methods The research was started from April 2016 to February 2017. The experiment was approved by the animal experimental ethics committee and was finished in the basic medical laboratory of Nagano University of Nursing in Japan. A total of 24 rats were divided into 3 groups averagely,and there were the control group（group A）,the tap-water bath group（group B） and the traditional Chinese medicine bath group（group C）. Group B rats used tap-water bath,and group C rats used traditional Chinese medicine bath,while the rats in group A did not bath. After bathing for 2 weeks,the pressure injury model was made on the rats＇ skin,and then the average of ulcer area and the maximum- minimum concentration difference were calculated by Image-J ;besides the healing rate,wound center temperature,skin moisture were compared among the three groups.Results For the 12 h pressure injury area after three groups rats model established,the group A was（137.060±18.258） mm2,Group B（123.310±14.969） mm2,group C （92.520±11.159） mm2（F=73.235,P〈0.05）;Image-J measures the average area of pressure injury picture among three groups and maximum-minimum concentration difference of picture（F=8.13,4.91;P〈0.01）.The rate of wound healing was statistically difference after the PI model at 12 hours,4 days,8 days,12 days （F=8.058, 12.024,17.360,26.006;P〈0.05）;however,the skin moisture had no statistical significance （P〉0.05）. Conclusions Baxianxiaoyao Decoction medicated bath is an effective way to prevent and treat pressure injury wound,and it can promote wound healing.

关 键 词：中草药 大鼠 压力性损伤 沐浴疗法 八仙逍遥汤 

分 类 号：R285.5[医药卫生—中药学]