补阳还五汤对气虚血瘀型急性脑梗死患者高凝状态的影响  

Effect of Buyang Huanwu Decoction on Hypercoagulable State of Patients with Acute Cerebral Infarction with Qi Deficiency and Blood Stagnation

作　　者：罗世希[1] 陈虹年 张相锋 Luo Shixi Chen Hongnian Zhang Xiangfeng(Department of Traditional Chinese Medicine ,Zunyi Traditional Chinese Medical Hospital ,Zunyi 563000, Chin)

机构地区：[1]贵州省遵义市中医院中医内科,遵义563000

出　　处：《世界中医药》2017年第9期2050-2053,共4页World Chinese Medicine

基　　金：贵州省卫生厅科学技术基金立项项目(gzwkj2008-1-040)

摘　　要：观察补阳还五汤对气虚血瘀型急性脑梗死患者血液高凝状态的影响。方法:选取2015年4月至2016年9月在遵义市中医院中医内科就诊的急性脑梗死患者60例,随机分为对照组及观察组,各30例,其中对照组患者接受神经内科常规西药治疗,观察组在对照组治疗方案基础上加用补阳还五汤。以4周为1个疗程,疗程结束后比较2组患者FMA(FuglMeyer)评分,血栓弹力图指标及外周血P-选择素浓度变化。结果:补阳还五汤可更明显提高急性脑梗死患者的运动能力,同时其延长R值和K值,下调α角、MA及CI数值,并且抑制了外周血P-选择素的水平。结论:补阳还五汤可明显改善气虚血瘀型急性脑梗死患者血压高凝状态,其可能是该方发挥临床疗效的可能机制之一。To observe the effects of Buyang Huanwu decoction on blood hypercoagulability in patients with acute cerebral infarction of qi deficiency and blood stasis syndrome. Methods： A total of 60 cases of acute cerebral infarction patients were included in the study,then randomly divided into control group（ 30 cases） and observation group（ 30 cases）. The control group received conventional western medicine treatment of neurology,and the observation group with Buyang Huanwu decoction based on western medicine. Take 4 weeks for a course of treatment. At the end of the treatment,FMA score,thrombus elasticity index and the concentration of P-selectin in peripheral blood were compared between the two groups. Results： Buyang Huanwu decoction could significantly improve the exercise capacity of patients with acute cerebral infarction,while prolonge the R and K values,reduce α angle,MA and CI values,and inhibit the level of P-selectin in peripheral blood. Conclusion： Buyang Huanwu decoction can improve the blood pressure hyper coagulability of patients with acute cerebral infarction of qi deficiency and blood stasis syndrome,which may be one of the possible mechanisms.

关 键 词：急性脑梗死 气虚血瘀型 高凝状态 血栓弹力图 P-选择素 

分 类 号：R289.5[医药卫生—方剂学] R543[医药卫生—中药学]