环磷酰胺诱导的小鼠骨髓抑制模型及中药对其防治作用机制研究进展  

Mouse Model of Cyclophosphamide-Induced Myelosuppression and Research Progress on Mechanism of Action of Chinese Meteria Medica in its treatment and prevention

作　　者：王成龙 赵东峰[1] 杨志烈 贾友冀 常君丽 王拥军[1] 杨燕萍 Wang Chenglong Zhao Dongfeng Yang Zhilie Jia Youji Chang Junli Wang Yongjun Yang Yanping(Spine institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Central Laboratory for Research, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Integrated Chinese and Western Medicine College, Binzhou Medical College, Yantai 264003, China Department of Orthopedics, Ruijin Hospital, Shanghai Jiao-Tong University Medical School, Shanghai 200025, China)

机构地区：[1]上海中医药大学附属龙华医院脊柱病研究所,上海200032 [2]上海中医药大学附属龙华医院科技中心实验室,上海200032 [3]滨州医学院中西医结合学院,烟台264003 [4]上海交通大学医学院附属瑞金医院骨科,上海200025

出　　处：《世界中医药》2017年第9期2252-2257,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81202708;81373667;81674006)

摘　　要：化疗后骨髓抑制容易导致患者发生感染或出血,严重影响患者治疗、预后和生命质量,甚至危及生命,给患者及家属带来很大痛苦。中医药防治化疗导致骨髓抑制越来越受到重视。随着骨髓抑制动物模型的建立、应用和成熟,中药防治化疗导致骨髓抑制机制的研究也取得许多进展,显出中药治疗的优势和前景。Patients with chemotherapy-induced myelosuppression is prone to infection or bleeding,which has a serious impact on their treatment,prognosis and quality of life and even endangers life and leads patients and their family to suffering. In recent years,traditional Chinese medicine in preventing and treating chemotherapy-induced myelosuppression have gradually garnered increasing attention. As the animal model of myelosuppression is being established,applied and mature,research on mechanism of Chinese meteria medica in preventing and treating chemotherapy-induced myelosuppression has made great achievements,showing the advantages and prospect of Chinese meteria medica in the treatment of this disease.

关 键 词：环磷酰胺 化疗 骨髓抑制 小鼠模型 机制研究 

分 类 号：R285.5[医药卫生—中药学]