人参皂甙等清除超氧阴离子自由基的研究  

Study on Superoxide Anion-Scavenging Effect of Ginsenosides-Related Glycosides

作　　者：龚国清[1] 张纯[1] 周曙[1] 孙晓明[1] 徐黻本 

机构地区：[1]中国药科大学药理学教研室

出　　处：《中国药科大学学报》1991年第1期41-43,共3页Journal of China Pharmaceutical University

摘　　要：筛选自由基清除剂常用黄嘌呤氧化酶氧化黄嘌呤产生O_2^-·,但此体系中黄嘌呤氧化酶易被药物抑制。Alkaline Dimethyl Sulfoxide-H_2O-Luminol system was used to investigate superoxide anion-scavenging effects of Ginsenosides (GS) , Gypenosides (GP) , Panax notoginseng saponins (PNS), and Panaxadiol (PA) in vitro. Chemiluminescence produced from the system mentioned above may be inhibited in dosedependent manner by GS, GP, PNS, PA, Caffeic acid and superoxide dismutase. Concentration of fifty percentage of inhibition (IC50) are 38.8, 46.4, 52.1 and 97.8 μg/ml for GS, GP, PNS, and PA, respectively. In conclusion, Ginsenosides-related glycosides may exhibit their pharmacological action through scavenging superoxide anion.

关 键 词：人参皂甙 自由基 超氧阴离子 

分 类 号：R282.710.5[医药卫生—中药学]