线粒体与慢性气道疾病  

Mitochondria and chronic airway disease

作　　者：王蕾[1] 李锋[1] 周新[1] Wang Lei Li Feng Zhou Xin(Department of Respiratory Medicine, Shanghai First People＇s Hospital, Shanghai Jiaotong University, Shanghai 200080, Chin)

机构地区：[1]上海交通大学附属第一人民医院呼吸科,200080

出　　处：《国际呼吸杂志》2017年第19期1511-1514,共4页International Journal of Respiration

基　　金：国家自然科学基金面上项目（81470218）;上海市科委“浦江人才项目”（14PJD027）

摘　　要：支气管哮喘（简称哮喘）和cOPD是两大主要的慢性气道疾病。线粒体存在于大多数真核细胞的细胞浆内，是具有独特特性的细胞器。线粒体通过遗传学、动力学、自噬和mtROS等多个环节，参与炎症浸润、气道重塑等肺组织病理过程。越来越多的研究表明，线粒体功能异常或正常功能受损与慢性气道疾病的病理生理机制有关。故本文拟就线粒体在哮喘和COPD中的作用及机制作一综述。Bronchial asthma （asthma） and chronic obstructive pulmonary disease （COPD） are two major chronic airway diseases. Mitochondria are particular organelles that present in the cytoplasm of most eukaryotic cells. Mitochondria are involved in inflammatory infiltration, airway remodeling and other pathological processes in the lung tissue through its genetics, dynamics, autophagy, mtROS, and so on. More and more studies have demonstrated that mitochondrial dysfunction or impaired mitochodrial function is involved in the pathophysiology of chronic airway diseases. Therefore, the article intends to review the role and mechanism of mitochondria in asthma and COPD.

关 键 词：线粒体 气道疾病 

分 类 号：R56[医药卫生—呼吸系统]