飞扬肠胃炎胶囊体外抑菌作用研究  

Study on the antimicrobial activity in vitro of Feiyang Changweiyan Capsules

作　　者：李瑶[1] 杨倩[2] 周丹 李骅[2] 史志辉 王四旺[2] 谢艳华[2] Li Yao YANG Qian ZHOU Dan LI Hua SHI Zhihui WANG Siwang XIE Yanhua(College of Pharmacy, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China Staff Room of Natural Pharmacology, School of Pharmacy, the Fourth Military Medical University, Shaanxi Province, Xi＇an 710032, China Shaanxi Junbisha Pharmaceutical Limited Company, Shaanxi Province, Xianyang 712000, China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]第四军医大学药学系天然药物学教研室,陕西西安710032 [3]陕西君碧莎制药有限公司,陕西咸阳712000

出　　处：《中国医药导报》2017年第28期21-24,共4页China Medical Herald

基　　金：陕西省科技统筹创新工程项目(S2017-ZDYFZDXM-SF-0131);陕西省科学技术研究发展计划项目(2015SF2-08-01)

摘　　要：目的探讨飞扬肠胃炎胶囊的体外抑菌效果。方法采用试管二倍稀释法联合琼脂平板法,以头孢曲松钠为阳性对照药,测定飞扬肠胃炎胶囊对大肠埃希菌、金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、β-溶血性链球菌、白色念珠菌的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。结果飞扬肠胃炎胶囊对大肠埃希菌(MIC为6.25 mg/mL)、金黄色葡萄球菌(MIC为1.56 mg/mL)、粪肠球菌(MIC为25.00 mg/mL)、铜绿假单胞菌(MIC为6.25 mg/mL)、β-溶血性链球菌(MIC为12.50 mg/mL)的体外抑菌作用较强,对白色念珠菌(MIC为100.00 mg/mL)的体外抑菌作用较弱。结论飞扬肠胃炎胶囊对大肠埃希菌、金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、β-溶血性链球菌具有较强的体外抑菌作用。Objective To investigate the antimicrobial activity in vitro of Feiyang Changweiyan Capsules. Methods The tube double dilution method and agar plate method were used to determine the minimum inhibitory concentrations （MIC） and minimum bactericidal concentrations （MBC） of Feiyang Changweiyan Capsules against Escherichia coil, Staphylococ- cus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, fl-hemolytic streptococcus and Candida albicans, taking Ceftri axone as positive control drug. Results The antibacterial activity of Feiyang Changweiyan Capsules against Escherichia coil （MIC was 6.25 mg/mL）, Staphylococcus aureus （MIC was 1.56 mg/mL）, Enterococcus faecalis （MIC was 25.00 mg/mL）, Pseudomonas aeruginosa （MIC was 6.25 mg/mL） and β-hemolytic streptococcus （MIC was 12.50 mg/mL） was stronger, which of Candida albicans （MIC was 100.00 mg/mL） was weaker. Conclusion Feiyang Changweiyan Capsules have stronger antimicrobial activity in vitro for Escherichia coil, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and β-hemolytic streptococcus.

关 键 词：飞扬肠胃炎胶囊 试管二倍稀释法 最小抑菌浓度 抑菌作用 

分 类 号：R285.5[医药卫生—中药学]