磁敏感加权成像测量脑铁沉积在帕金森病中的临床应用  

Susceptibility-weighted imaging of clinical application of brain iron depositionin in patients with Parkinson disease

作　　者：贺娟[1] 呼日乐特木尔 韩晓东[2] 孙明[1] 张春雨[1] 段美庆[3] 王智光[1] 张国华[1] 刘桂英[1] HE Juan Huriletemuer HAN Xiaodong SUN Ming ZHANG Chunyu DUAN Meiqing WANG Zhiguang ZHANG Guohua LIU Guiying(Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China Department of Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China)

机构地区：[1]内蒙古医科大学附属医院神经内科,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院影像科,内蒙古呼和浩特010059 [3]内蒙古医科大学附属医院检验科,内蒙古呼和浩特010059

出　　处：《中国医药导报》2017年第28期117-120,共4页China Medical Herald

基　　金：内蒙古自治区自然科学基金面上项目(2014MS08105);内蒙古自治区卫计委科研计划项目(201301056)

摘　　要：目的通过磁敏感加权成像技术(SWI)定量研究帕金森病(PD)脑铁沉积,探讨其临床应用价值。方法收集2010年6月~2016年6月于内蒙古医科大学附属医院神经内科诊治的40例帕金森病患者为PD组,另选同期健康志愿者20例为对照组(NC组)。所有PD患者进行Hoehn&Yahr分级,分期≤1.5为早期组(PD1组)23例,分期>1.5为中晚期(PD2组)组17例。采用3.0TMR系统对各组中脑核团行常规MRI平扫和SWI序列扫描,分别测量各核团位相值,并对测量结果进行比较和相关性分析。结果 PD组与NC组双侧尾状核(CN)、苍白球(GP)、双侧壳核(PU)、红核(RN)、黑质(SN)相位值比较均有所增加,提示有较多的铁沉积。PD1组、PD2组与NC组中SN、GP和RN的相位值比较,差异有统计学意义(P<0.05),但三组PU、CN的相位值比较,差异无统计学意义(P>0.05);PD2组SN、GP、CN相位值与NC组比较,差异有统计学意义(P<0.05),但PD1组与PD2组相位值比较,差异无统计学意义(P>0.05)。结论 SWI可反映脑内铁沉积,可以通过测量相关脑核团信号强度并计算出相位值以评价脑铁沉积,为PD患者的辅助诊断与治疗提供一定帮助。Objective To clinical value of iron deposition in brain of Parkinson disease （PD） by susceptibility weighted imaging （SWI）. Methods From June 2010 to June 2016, in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, 40 PD patients were selected as PD group, 20 healthy volunteers were enrolled into the control group （NC group） at the same time. All PD patients were graded by Hoehn＆Yahr, stage≤ 1.5 as early phase group （PD1 group） 23 cases, stage 〉 1.5 as middle and advanced phase （PD2 group） 17 cases, brain nuclei of each group were examinated by MRI and SWI with 3.0TMR system, and the results were compared and analyzed. Results The phase values of caudate nucleus （CN）, globus pallidus （GP）, putamen （PU）, red nucleus （RN） and substantia nigra （SN） of patients in PD group increased compared with NC group, which indicated there was more iron deposits. The phase values of SN, GP and RN in PD1 group, PD2 group and NC group were compared, the differences were statistically significant （P 〈 0.05）, but the phase values of PU, CN in three groups were compared, the differences were not statistically significant （P 〉 0.05）; the phase values of SN, GP, CN in PD2 group were compared with NC group, the differences were statistically significant （P 〈 0.05）, but these in PD1 group and PD2 group were compared, the differences were not statistically significant （P 〉 0.05）. Conclusion SWI can reflect the iron deposition in the brain, and it can be used to evaluate the brain iron deposition by measuring the signal intensity of related brain nuclei and calculating the phase value. It can provide some help for diagnosis and treatment of the patients.

关 键 词：磁敏感加权成像 帕金森病 铁沉积 

分 类 号：R445.2[医药卫生—影像医学与核医学]