初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系  

Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients

作　　者：崔丽梅[1] 刘翠平[1] 傅汉菁[2] 严晔华[1] 郑晓敏[1] 陶静[1] 冯建萍[2,3] 袁明霞 杨金奎[2,3] Cui Limei Liu Cuiping Fu Hanjing Yan Yehua Zheng Xiaomin Tao Jing Feng Jianping Yuan Mingxia Yang Jinkui(Department of Endocrinology, Beijing Chuiyangliu Hospital, Beijing 100022, China Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China)

机构地区：[1]北京市垂杨柳医院内分泌科,北京100022 [2]首都医科大学附属北京同仁医院内分泌科,北京100730 [3]糖尿病防治研究北京市重点实验室,北京100730

出　　处：《首都医科大学学报》2017年第2期167-171,共5页Journal of Capital Medical University

基　　金：国家自然科学基金(81370946;81400824;81300726);北京市自然科学基金(7131005)~~

摘　　要：目的探讨初诊2型糖尿病(type 2 diabetes mellitus,T2DM)病人血清维生素D与甲状腺功能及临床指标的关系。方法选择北京市垂杨柳医院内分泌科2015年5月至2016年10月的初诊2型糖尿病病人239例,根据血清25-羟维生素D[25-hydroxy vitamin D,25(OH)D]值分为:≥30 ng/mL为正常组、20 ng/mL≤25(OH)D<30 ng/mL为不足组、10 ng/mL≤25(OH)D<20 ng/mL为缺乏组、<10 ng/mL为严重缺乏组,比较血清25(OH)D与临床指标及甲状腺功能的关系。结果初诊2型糖尿病病人血清维生素D缺乏的患病率为56.9%,随着血清25(OH)D下降,年龄、糖化血红蛋白(glycosylate hemoglobin,HbA1c)、促甲状腺激素(thyroid stimulating hormone,TSH)逐渐增加,各组间比较差异有统计学意义(P<0.05)。线性回归分析结果显示血钙(calcium,Ca)、甲状旁腺素(parathyroid hormone,PTH)与血清25(OH)D呈独立正相关(P<0.05);性别、年龄、吸烟、HbA1c、TSH与血清25(OH)D呈独立负相关(P<0.05)。结论女性、年龄、吸烟、HbA1c、TSH是初诊2型糖尿病病人血清25(OH)D缺乏的独立危险因素。Objective To observe relation between serum vitamin D level and thyroid function,clinical characteristics in the newly-diagnosed type 2 diabetes mellitus（T2DM） patients.Methods A total of 239 patients with the newly-diagnosed T2DM were selected in Department of Endocrinology,Beijing Chuiyangliu Hospital from May 2015 to October 2016.According to serum 25-hydroxyvitamin D [25（OH）D] level,these patients were divided into four groups：normal group ≥30 ng/mL,insufficiency group 20 ng/mL≤25（OH）D〈30 ng/mL,deficiency group 10 ng/mL≤25（OH）D〈20 ng/mL and severe deficiency group〈10 ng/mL.Clinical characteristics and thyroid function were compared in these groups.Results The incidence of serum 25（OH）D deficiency was 56.9% in the newly-diagnosed T2DM group.There were significant differences in age,glycosylated hemoglobin （HbA1c）,thyroid stimulating hormone （TSH） in these groups （P〈0.05）.The linear regression analysis showed that serum calcium （Ca）,parathyroid hormone （PTH） were positively correlated with serum 25（OH）D （P〈0.05）,but gender,age,smoking,HbA1c,TSH were negatively correlated with serum 25（OH）D （P〈0.05）.Conclusion Female,age,smoke,HbA1c,TSH are important risk factors for deficiency of serum 25（OH）D in the newly-diagnosed T2DM patients.

关 键 词：2型糖尿病 维生素D 甲状腺功能 促甲状腺激素 

分 类 号：R58[医药卫生—内分泌]