人附睾蛋白4对急性心力衰竭患者预后的预测价值  

Human Epididymis Protein 4 Predicts Outcome in Patients With Acute Heart Failure

作　　者：刘琳[1] 刁云辉[2] 杨守忠[1] 李京倡[1] 

机构地区：[1]南阳市中心医院心血管内科1病区,河南南阳473003 [2]南阳市中心医院消化内科1病区,河南南阳473003

出　　处：《医学与哲学（B）》2017年第9期28-30,38,共4页Medicine & Philosophy(B)

摘　　要：探讨人附睾蛋白4(HE4)对急性心力衰竭患者预后的预测价值。入组2015年1月~2016年2月住院的急性心力衰竭患者178例,检测患者血清中HE4的表达水平,并对患者进行随访,记录患者死亡和再住院情况。HE4在心力衰竭组明显高于健康对照组[(7.8±0.6)ng/ml vs.(2.2±0.5)ng/ml,P<0.05)],且随心功能分级的恶化,HE4水平明显升高[(5.3±0.4)ng/ml vs.(7.6±0.5)ng/ml vs.(9.7±0.6)ng/ml,P<0.05)],多因素Cox生存分析表明:HE4是预测急性心力衰竭患者预后的独立预测指标(χ2=10.26,HR95%CI:2.25(0.67~4.14),P<0.001),进一步分析显示:HE4>7.5ng/ml的患者死亡和再入院的风险是HE4≤7.5ng/ml的患者的7.12倍。HE4能够反映急性心力衰竭的严重程度,并且能够预测急性心力衰竭患者的预后。We aimed to evaluate the power of human epididymis protein 4（ HE4） to predict outcomes in patients with acute heart failure. 178 patients with acute heart failure were enrolled from January 2015 to February 2016 in our hospital. We detected the level of HE4 in these patients and recorded the events of rehospitalization due to heart failure and any cause of death. HE4 is higher in patients with acute heart failure compared with that in patients in the control group [（ 7.8±0.6） ng/ml vs.（ 2.2±0.5） ng/ml,P〈0.05） ],the level of HE4 increased as the classification of cardiac function worsen [（ 5.3±0.4） ng/ml vs.（ 7.6 ±0.5） ng/ml vs.（ 9.7± 0.6） ng/ml,P〈0.05） ]. Multivariate Cox analysis demonstrated that HE4 could independently predict rehospitalization and mortality. Patients with HE47.5ng/ml had a 7.12-fold higher risk of rehospitalization and mortality than patients with HE4≤7.5ng/ml.The level of HE4 can reflect the severe of acute heart failure,and HE4 can predict the prognosis of patients with acute heart failure.

关 键 词：急性心力衰竭 人附睾蛋白4 预后 

分 类 号：R541.6[医药卫生—心血管疾病]