粉末冶金制备TNZS基生物材料的体外组织相容性  

Histocompatibility in Vitro of TNZS-Based Biomaterials Prepared by Powder Metallurgy

作　　者：朱利华[1] 吴刘军 许晓静[1] 陈婷卓 Zhu Lihua Wu Liujun Xu Xiaojing Chen Tingzhuo(Engineering Institute of Advanced Manufacturing and Modern Equipment Technology, Jiangsu University, Zhenjiang 212013, China)

机构地区：[1]江苏大学先进制造与现代装备技术工程研究院,江苏镇江212013

出　　处：《稀有金属材料与工程》2017年第9期2601-2606,共6页Rare Metal Materials and Engineering

基　　金：江苏省高校自然科学基金重大项目(11KJA430004);江苏大学拔尖人才工程基金(1211110001)

摘　　要：采用高能球磨与冷压烧结相结合的粉末冶金法制备了TNZS、5%TiO_2/TNZS及5%HA/TNZS(质量分数,下同)生物材料,并研究了TiO_2和HA的添加对TNZS体外组织相容性的影响。结束表明:3种TNZS基生物材料均无细胞毒性;5%TiO_2/TNZS和5%HA/TNZS表面在1,3,5和7 d的细胞相对增殖抑制率CPIR值大幅低于TNZS组,TiO_2和HA的添加显著提高了TNZS材料表面的细胞增殖速度,增强了其细胞增殖能力,更有助于诱导成骨细胞的体外增殖;3种TNZS基材料表面贴附的成骨细胞伪足伸展状态良好,而5%TiO_2/TNZS表面贴附的成骨细胞分布更加均匀。TNZS,5%TiO_2/TNZS and 5%HA/TNZS（mass fraction） bio-medical materials were prepared by powder metallurgy combining high-energy milling with cold pressed sintering. Histocompatibility in vitro of the three TNZS-based materials was studied. The results show that the three materials have no cytotoxicity; CPIR on the surface of 5%TiO_2/TNZS and 5%HA/TNZS for 1,3,5 and 7 d is significantly lower than that of TNZS group,indicating that the addition of TiO_2 and HA can accelerate the cell proliferation on the surface of TNZS material and favors induction of proliferation of osteoblasts in vitro; pseudopodium extension of osteoblasts attached to the surface of the three materials are in good condition; the distribution of osteoblasts attached to the surface of 5%TiO_2/TNZS is more uniform.

关 键 词：粉末冶金 TNZS基生物材料 体外组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程] TF125[医药卫生—基础医学]