水热处理镁离子改性改善纯钛体外骨传导性的研究  

Improved in Vitro Osteoconductivity of Pure Titanium Modified with Magnesium by Hydrothermal Treatment

作　　者：徐玲利[1] 史兴岭[1] 朱治愿[1] 王泽鑫[1] Xu Lingli Shi Xingling Zhu Zhiyuan Wang Zexin(Jiangsu University of Science and Technology, Zhenjiang 212003, China)

机构地区：[1]江苏科技大学,江苏镇江212003

出　　处：《稀有金属材料与工程》2017年第9期2613-2617,共5页Rare Metal Materials and Engineering

基　　金：江苏科技大学科研基金(635061402);江苏高校优势学科建设工程资助项目

摘　　要：在200℃,0.1 mol/L的MgCl_2溶液中对纯钛进行了水热处理,以期改善其生物活性。采用多种分析手段对水热处理前后试样的形貌、润湿性能及表面化学成分进行了分析;采用模拟体液浸泡法评价了处理前后试样的体外骨传导性。水热处理在试样表面形成了纳米氧化钛颗粒,但并没有改变试样的微米尺度的形貌,经过水热处理的试样表现出了超亲水性。水热处理成功地将Mg元素复合至钛表面;在MgCl_2溶液中进行水热处理时,Mg元素主要以钛酸镁形式存在,而在pH为9.5的MgCl_2的溶液中进行水热处理时,Mg元素主要以Mg(OH)_2形式存在。在SBF中浸泡3 d后,水热处理试样表面可观察到羟基磷灰石球状晶簇,而未经处理的试样表面则未能发现沉积,此外,过高的Mg复合量抑制了羟基磷灰石的形核长大。结果表明,水热处理在保持种植体宏观形貌不受影响的前提下可作为种植体生产的最后工序以提高其骨结合性。Pure titanium was hydrothermally treated in 0.1 mol/L MgCl_2 solution with different pH at 200 °C for 24 h in order to improve its bioactivity. Surface morphology,roughness,wettability and chemical composition were characterized with sophisticated equipments before and after treatment. Simulated body fluid immersion experiment was conducted to examine in vitro osteoconductivity. Results indicate that hydrothermal treatment preserves the macro topography of polished substrates although nano-sized precipitations are observed and these surfaces show superhydrophilicity. Magnesium titanate is formed on titanium surface after hydrothermal treatment in MgCl_2 solution; however,under high pH,Mg（OH）_2 precipitated from the solution. Typical apatite spheres are observed on hydrothermally treated samples after immersion in SBF for 3 d. However,as Mg amount incorporated into titanium surface increases,the precipitation is depressed. The hydrothermal treatment is a promising finial treatment for fabricating titanium implants with good bioactivity.

关 键 词：纯钛 水热处理 镁 羟基磷灰石 骨传导性 

分 类 号：TG178[金属学及工艺—金属表面处理]