成骨细胞与软骨细胞在骨性关节炎中的相互作用综述  

A review of interactions between osteoblasts and chondrocytes in osteoarthritis

作　　者：陈高扬[1] 张桂珍[1] 王庆宇[1] 杜珍武[1] 宋旸[1] 

机构地区：[1]吉林大学第二医院,骨科长春130000

出　　处：《中国体视学与图像分析》2017年第2期230-237,共8页Chinese Journal of Stereology and Image Analysis

基　　金：吉林省卫计委项目(No.20132003);吉林大学白求恩基金项目(No.2015409);吉林省科技厅项目(No.20140311066YY;2015032022ZG);吉林省发改委项目(No.2014G073)

摘　　要：骨性关节炎是当前世界范围内最常见的关节疾病,常侵犯膝关节、髋关节、手和脊柱等。是老年人群致残的最常见病因之一,并严重影响老年人的生活质量。当前普遍的观点认为骨关节炎(OA)影响受累关节内的所有结构,并最终导致软骨的退化。当前软骨下骨的变化受到更多的关注,因为随着疾病的进展及软骨细胞的缺失,软骨下骨也会发生结构性的改变。关节软骨和软骨下骨的变化受软骨细胞和成骨细胞的调节,这两种细胞在维持这些组织的完整性和功能方面扮演着重要角色。有证据表明,软骨细胞和骨细胞之间存在化学串扰,骨细胞能通过细胞间信号传导促进软骨细胞代谢。这些疾病发展过程中细胞功能的改变将使我们获得新的疾病标志物。的确,如果软骨和软骨下骨表现为一个相互联系的功能单位,那么对于这两种细胞研究的深入以及骨性关节炎的诊断和治疗将能得到巨大的推动。Osteoarthritis （OA） is the most common joint disease worldwide. It primarily affects the knee, hip, hands, and spine. It is a leading cause of disability in the elderly population and seriously affects their quality of life. It is now a general agreement that OA involves all structures in affected joints, leads to cartilage degradation. Particularly, the changes in the subchondral bone are more of a concern because characteristic changes occur in this tissue as the disease progresses, either in parallel, or contributing to, the loss of cartilage volume and quality. Changes in both the articular cartilage and the subchondral bone are regulated by the cells of chondrocytes osteoblasts, which play an important role in maintaining the in- tegrity and function of these tissues. There is evidence of chemical crosstalk between chondrocytes and osteoblasts. Osteoblasts can promote chondrocyte metabolism through intercellular chemical crosstalk. The altered cell function during the progression of OA will enable us to obtain new disease markers. Indeed, if the cartilage and subchondral bone behave as an interconnected functional unit, normalization of cell behavior in one compartment may have benefits in both tissues and provide new methods for the diagnosis and treatment of osteoarthritis

关 键 词：骨关节炎 关节软骨 软骨下骨 成骨细胞 软骨细胞 发病机理 

分 类 号：R684.3[医药卫生—骨科学]