P-gp抑制剂对蓬子菜活性成分肠吸收的影响  

Intestinal loop model for effect of P-gp inhibitor on intestinal absorption of active ingredient from Galiumverum L.

作　　者：崔明宇[1] 王洪梅[1] 李聪慧[1] 张凯[1] 孔晓悦 马英丽[1] 

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《哈尔滨商业大学学报（自然科学版）》2017年第4期390-393,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：黑龙江省自然科学基金项目(H2015044);黑龙江省教育厅项目(12531625);国家自然科学基金项目(201281274034);黑龙江中医药大学研究生创新科研项目(yjscx2016049)

摘　　要：考察P-gp抑制剂对蓬子菜中活性成分肠吸收的促进作用.采用大鼠肠襻模型及HPLC测定方法,以活性成分DXG的剩余百分数(R%)和肠吸收转化率(A%)为评价指标,考察P-gp抑制剂对蓬子菜中活性成分肠吸收的影响.结果表明,与对照组相比,各组DXG剩余百分数减少,单位时间吸收转化率增加,蓬子菜中活性成分的肠吸收增加.P-gp抑制剂通过竞争性抑制作用,对蓬子菜中活性成分的肠吸收具有一定促进作用,可提高蓬子菜活性成分的生物利用度,为蓬子菜的新药研究提供新的科学依据.To study on the effect of P-gp inhibitor onintestinal absorption of active ingredient from Galiumverum L.,the intestinal loop model and HPLC were used. Percentage of residual and conversion rate of absorption were evaluation parameter. Results indicated that compared with the control group,percentage of residual was decreasing and conversion rate of absorption was increasing respectively. Absorption of active ingredient from Galiumverum L.was improved well. P-gp inhibitor could increase intestinal absorption and improve the bioavailability of active ingredient from Galiumverum L.,which canprovide the basis for research of Galiumverum L.

关 键 词：蓬子菜 DXG P-gp抑制剂 肠吸收 

分 类 号：R285[医药卫生—中药学]