戊型肝炎病毒感染慢性化的研究进展  

Research advances in chronicity of hepatitis E virus infection

作　　者：马元吉[1] 唐红[1] 

机构地区：[1]四川大学华西医院感染性疾病中心四川大学生物治疗国家重点实验室感染性疾病研究室,成都610041

出　　处：《中华肝脏病杂志》2017年第10期785-788,共4页Chinese Journal of Hepatology

摘　　要：戊型肝炎病毒（HEV）感染通常引起急性肝炎，疾病呈自限性发展过程，一般在6个月内临床康复，预后良好。近年来的研究发现，HEV感染在特殊情况下也可呈现出感染慢性化，表现为HEV急性感染后至少6个月仍存在肝功能的持续异常，且血清、粪便和（或）肝组织仍可检出病毒核酸。HEV感染慢性化主要发生于免疫功能不全者，临床不多见，但危害大。了解HEV感染慢性化的发生机制、临床表现、治疗及预防措施，有助于临床医师制定科学有效的管理方案，改善患者预后。现就相关问题进行介绍，以提高临床医师对该病的认识水平。Hepatitis E virus （HEV） infection usually causes acute hepatitis and has a self-limiting progression. The patients often recover within 6 months with good prognosis. Recent studies have found that HEV infection may become chronic in special situations, which manifests as persistent liver function abnormalities for at least 6 months after acute HEV infection and the presence of ~ral nucleic acid in serum, feces, and/or liver tissue. Chronicity of HEV infection mainly occurs in immunocompromised patients, and it is rare but very dangerous in clinical practice. An understanding of the pathogenesis, clinical manifestations, treatment methods, and preventive measures of chronicity of HEV infection helps clinical physicians develop an effective management regimen and improve patient prognosis. This article introduces related issues, in order to raise the awareness of this disease among clinical physicians.

关 键 词：肝炎病毒  戊型 治疗 预防 慢性感染 发病机制 

分 类 号：R373.21[医药卫生—病原生物学]