多囊卵巢综合征患者子代发生的远期改变  

Long-term effects of polycystic ovary syndrome on the offspring

作　　者：沈丹 王芳芳[1] 姜舟 曲凡[1] 

机构地区：[1]浙江大学医学院附属妇产科医院中医妇科,浙江杭州310006 [2]杭州市红十字会医院儿科,浙江杭州310003 [3]浙江大学医学院附属邵逸夫医院新生儿监护中心,浙江杭州310016

出　　处：《浙江大学学报（医学版）》2017年第3期300-304,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省杰出青年科学基金(LR16H040001);国家自然科学基金(81401167)

摘　　要：多囊卵巢综合征(PCOS)是一种生殖功能障碍与代谢异常并存的内分泌紊乱综合征,病因不明。雄激素分泌过多是PCOS的主要特征之一。PCOS子代生殖系统、代谢系统、神经精神系统均有不同程度的远期改变。PCOS子代有促性腺激素释放激素和促性腺激素分泌增加、卵巢形态改变、性激素分泌异常的表现,脂肪和糖代谢紊乱现象,子代抑郁症及自闭症的风险增加,但是目前缺乏直接相关的证据,相关机制仍需进一步研究。Polycystic ovary syndrome （PCOS） is an endocrine disorder with reproductive dysfunction and abnormal metabolic syndrome. However, its etiology is unknown yet. Androgen hypersecretion is one of the main features of PCOS. It has been found that PCOS has various effects on the offspring in reproductive, metabolic and nervous systems, including：increasing secretion of gonadotropin-releasing hormone and luteinizing hormone, ovarian morphological changes and abnormal secretion of sex hormones, leading to disorders of lipid and glucose metabolism, and increasing the risks of depression and autism. However, there is still lack of direct evidence, and more studies should be conducted on the underlying mechanism in future.

关 键 词：多囊卵巢综合征 雄激素类 子代 自闭症 抑郁症 综述 

分 类 号：R711.75[医药卫生—妇产科学] R722[医药卫生—临床医学]